DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, SU | ko |
dc.contributor.author | Seo, JH | ko |
dc.contributor.author | Choi, YH | ko |
dc.contributor.author | Lee, Seung Seob | ko |
dc.date.accessioned | 2007-11-06T06:13:34Z | - |
dc.date.available | 2007-11-06T06:13:34Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-08 | - |
dc.identifier.citation | SENSORS AND ACTUATORS A-PHYSICAL, v.130, no.31, pp.267 - 272 | - |
dc.identifier.issn | 0924-4247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/1828 | - |
dc.description.abstract | A disposable biochip for measuring percent hemoglobin A1c, a glycosylated hemoglobin (HbA1c), in blood is presented, in which a air of p interdigitated array electrodes, a micropump, and a microchannel were on-chip integrated by bonding a glass wafer and a polydimethylsiloxane (PDMS) layer. The ratio of HbA1c to hemoglobin, %HbA1c, represents the average glucose level during the life span of red blood cells, and thus, it can be a more reliable and accurate index of diabetes. For %HbA1c measurement, the blood sample was split into two streams, one with HbA1c and the other without HbA1c by binding of HbA1c with in-amino-phenylboronic acid agarose beads. Each stream passed by the interdigitated electrodes resulting in an electric signal via an electrochemical reaction. The %HbA1c was calculated with both signals. A first device of 40 mm x 20 mm x 3 mm was fabricated by bonding two glass wafers and two PDMS layers with a vertical sample reservoir. A second device of 75 mm x 25 turn x 1.5 mm was produced by bonding one glass wafer and one PDMS layer yielding a simplified configuration compared to the first device. For verifying the devices, blood suspensions were transported and cell lysis was tested. A 50-mu L blood suspension extracted from a mouse was mixed with ethylenediaminetetraacetic acid, diluted with phosphate buffered saline to lower its viscosity, and the suspension was then transported at approximately 30 mu m/s in the microchannel by the micropump, which produced oxygen gas. The condition for blood lysis was determined empirically with 2% Triton X-100, a neutral detergent. (c) 2006 Elsevier B.V. All fights reserved. | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.subject | GLUCOSE | - |
dc.subject | SENSOR | - |
dc.title | Fabrication of a disposable biochip for measuring percent hemoglobin Alc (%HbAlc) | - |
dc.type | Article | - |
dc.identifier.wosid | 000239295000039 | - |
dc.identifier.scopusid | 2-s2.0-33745987005 | - |
dc.type.rims | ART | - |
dc.citation.volume | 130 | - |
dc.citation.issue | 31 | - |
dc.citation.beginningpage | 267 | - |
dc.citation.endingpage | 272 | - |
dc.citation.publicationname | SENSORS AND ACTUATORS A-PHYSICAL | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Seung Seob | - |
dc.contributor.nonIdAuthor | Son, SU | - |
dc.contributor.nonIdAuthor | Seo, JH | - |
dc.contributor.nonIdAuthor | Choi, YH | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordAuthor | disposable biochip | - |
dc.subject.keywordAuthor | HbAlc | - |
dc.subject.keywordAuthor | %HbAlc | - |
dc.subject.keywordAuthor | interdigitated array (IDA) electrode | - |
dc.subject.keywordAuthor | blood lysis | - |
dc.subject.keywordAuthor | micropump | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | SENSOR | - |
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