DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Won-il | ko |
dc.contributor.author | Osei-Hyiaman, Douglas | ko |
dc.contributor.author | Park, Ogyi | ko |
dc.contributor.author | Liu, Jie | ko |
dc.contributor.author | Batkai, Sandor | ko |
dc.contributor.author | Mukhopadhyay, Partha | ko |
dc.contributor.author | Horiguchi, Norio | ko |
dc.contributor.author | Harvey-White, Judith | ko |
dc.contributor.author | Marsicano, Giovanni | ko |
dc.contributor.author | Lutz, Beat | ko |
dc.contributor.author | Gao, Bin | ko |
dc.contributor.author | Kunos, George | ko |
dc.date.accessioned | 2010-04-06T07:43:55Z | - |
dc.date.available | 2010-04-06T07:43:55Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-03 | - |
dc.identifier.citation | CELL METABOLISM, v.7, no.3, pp.227 - 235 | - |
dc.identifier.issn | 1550-4131 | - |
dc.identifier.uri | http://hdl.handle.net/10203/17563 | - |
dc.description.abstract | Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism. Here we report that the steatosis induced in mice by a low-fat, liquid ethanol diet is attenuated by concurrent blockade of cannabinoid CB1 receptors. Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment. Ethanol feeding increases the hepatic expression of CB1 receptors and upregulates the endocannabinoid 2-arachidonoylglycerol (2-AG) and its biosynthetic enzyme diacylglycerol lipase beta selectively in hepatic stellate cells. In control but not CB1 receptor-deficient hepatocytes, coculture with stellate cells from ethanol-fed mice results in upregulation of CB1 receptors and lipogenic gene expression. We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation. | - |
dc.description.sponsorship | This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism (NIH). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | CELL PRESS | - |
dc.title | Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver | - |
dc.type | Article | - |
dc.identifier.wosid | 000253727300009 | - |
dc.identifier.scopusid | 2-s2.0-38649114788 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 227 | - |
dc.citation.endingpage | 235 | - |
dc.citation.publicationname | CELL METABOLISM | - |
dc.identifier.doi | 10.1016/j.cmet.2007.12.007 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jeong, Won-il | - |
dc.contributor.nonIdAuthor | Osei-Hyiaman, Douglas | - |
dc.contributor.nonIdAuthor | Park, Ogyi | - |
dc.contributor.nonIdAuthor | Liu, Jie | - |
dc.contributor.nonIdAuthor | Batkai, Sandor | - |
dc.contributor.nonIdAuthor | Mukhopadhyay, Partha | - |
dc.contributor.nonIdAuthor | Horiguchi, Norio | - |
dc.contributor.nonIdAuthor | Harvey-White, Judith | - |
dc.contributor.nonIdAuthor | Marsicano, Giovanni | - |
dc.contributor.nonIdAuthor | Lutz, Beat | - |
dc.contributor.nonIdAuthor | Gao, Bin | - |
dc.contributor.nonIdAuthor | Kunos, George | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | HUMDISEASE | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | ACID SYNTHESIS | - |
dc.subject.keywordPlus | ABDOMINAL OBESITY | - |
dc.subject.keywordPlus | ETHANOL | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | STEATOSIS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | RATS | - |
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