DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, SY | ko |
dc.contributor.author | Park, SJ | ko |
dc.contributor.author | Kwon, MJ | ko |
dc.contributor.author | Jeong, TS | ko |
dc.contributor.author | Bok, SH | ko |
dc.contributor.author | Choi, WY | ko |
dc.contributor.author | Jeong, Won-il | ko |
dc.contributor.author | Ryu, SY | ko |
dc.contributor.author | Do, SH | ko |
dc.contributor.author | Lee, CS | ko |
dc.contributor.author | Song, JC | ko |
dc.contributor.author | Jeong, KS | ko |
dc.date.accessioned | 2010-04-06T07:34:59Z | - |
dc.date.available | 2010-04-06T07:34:59Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-01 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR BIOCHEMISTRY, v.243, no.1, pp.153 - 160 | - |
dc.identifier.issn | 0300-8177 | - |
dc.identifier.uri | http://hdl.handle.net/10203/17562 | - |
dc.description.abstract | Quercetin is a flavonoid molecule ubiquitous in nature and functions as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. Dose- and time-dependent effect of quercetin has been investigated on proinflammatory cytokine expression and NO production, focusing on its effects on the MAP kinases and the NF-kappaB signal transduction pathways in LPS-stimulated RAW 264.7 cells by using RT-PCR and immunoblotting. Quercetin strongly reduced activation of phosphorylated ERK kinase and p38 MAP kinase but not JNK MAP kinase by LPS treatment. In addition, quercetin treatment inhibited NF-kappaB activation through stabilization of the NF-kappaB/IkappaB complex and I B degradation and proinflammatory cytokines and NO/iNOS expression. Quercetin may exert its anti-inflammatory and immunomodulatory properties in the effect molecules such as proinflammatory cytokines and NO/iNOS by suppressing the activation of ERK and p38 MAP kinase, and NF-kappaB/IkappaB signal transduction pathways. | - |
dc.description.sponsorship | This work was partly supported by Kyungpook National University Research Team Fund, 2002. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | SPRINGER | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | NITRIC-OXIDE PRODUCTION | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | MURINE MACROPHAGES | - |
dc.subject | TYROSINE KINASE | - |
dc.subject | INTERLEUKIN-6 | - |
dc.subject | RAW-264.7 | - |
dc.subject | P38 | - |
dc.subject | LPS | - |
dc.subject | INHIBITION | - |
dc.title | Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappa B pathway in lipopolysaccharide-stimulated macrophage | - |
dc.type | Article | - |
dc.identifier.wosid | 000179883900020 | - |
dc.identifier.scopusid | 2-s2.0-0037281331 | - |
dc.type.rims | ART | - |
dc.citation.volume | 243 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 153 | - |
dc.citation.endingpage | 160 | - |
dc.citation.publicationname | MOLECULAR AND CELLULAR BIOCHEMISTRY | - |
dc.identifier.doi | 10.1023/A:1021624520740 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jeong, Won-il | - |
dc.contributor.nonIdAuthor | Cho, SY | - |
dc.contributor.nonIdAuthor | Park, SJ | - |
dc.contributor.nonIdAuthor | Kwon, MJ | - |
dc.contributor.nonIdAuthor | Jeong, TS | - |
dc.contributor.nonIdAuthor | Bok, SH | - |
dc.contributor.nonIdAuthor | Choi, WY | - |
dc.contributor.nonIdAuthor | Ryu, SY | - |
dc.contributor.nonIdAuthor | Do, SH | - |
dc.contributor.nonIdAuthor | Lee, CS | - |
dc.contributor.nonIdAuthor | Song, JC | - |
dc.contributor.nonIdAuthor | Jeong, KS | - |
dc.type.journalArticle | Article | - |
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