DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Hee-Man | ko |
dc.contributor.author | Park, Chan-Woo | ko |
dc.contributor.author | Bae, Pan-Kee | ko |
dc.contributor.author | Ahn, Tae-Bin | ko |
dc.contributor.author | Seo, Bum-Kyoung | ko |
dc.contributor.author | Chung, Bong-Hyun | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2013-08-08T06:06:58Z | - |
dc.date.available | 2013-08-08T06:06:58Z | - |
dc.date.created | 2013-07-08 | - |
dc.date.created | 2013-07-08 | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY B, v.1, no.24, pp.3035 - 3043 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | http://hdl.handle.net/10203/174926 | - |
dc.description.abstract | Superparamagnetic iron oxide nanoparticles are widely used as nanoprobes for magnetic resonance imaging (MRI). In this study, a novel type of cross-linked magnetic nanoparticle was developed in an effort to improve the structural stability of amphiphilic polymer-coated iron oxide nanoparticles. Iron oxide nanocrystals were coated with a cross-linkable amphiphilic graft copolymer, poly(succinimide) grafted with folate-conjugated polyethylene glycol (PEG) and alkyl chains. The tumor-specific targeting ligand, folate, was included to target and detect cancer cells. The hydrophobic portions of the amphiphilic copolymer on the surfaces of the nanoparticles were cross-linked via an aminolysis reaction between the succinimide units and a bifunctional primary amine. The folate-conjugated cross-linked magnetic nanoparticles (F-CLMNPs) were 40 nm in diameter and displayed a low cytotoxicity, even at relatively high concentrations. The F-CLMNPs exhibited highly efficient intracellular uptake into KB cells, which overexpress the folate receptor, as determined by fluorescence microscopy, flow cytometry, and Prussian blue staining. In vivo MR images of a mouse bearing a KB cell tumor displayed a 75% drop in the T2 signal in the tumor tissues within 3 hours. These results indicated that the F-CLMNPs accumulated at the tumor site and were highly effective for tumor detection using in vivo MRI techniques. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | IRON-OXIDE NANOPARTICLES | - |
dc.subject | CONTRAST AGENTS | - |
dc.subject | SUPERPARAMAGNETIC NANOPARTICLES | - |
dc.subject | BIOMEDICAL APPLICATIONS | - |
dc.subject | DELIVERY-SYSTEM | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | CELL-LINES | - |
dc.subject | POLYMER | - |
dc.subject | MICELLES | - |
dc.subject | ACID) | - |
dc.title | Folate-conjugated cross-linked magnetic nanoparticles as potential magnetic resonance probes for in vivo cancer imaging | - |
dc.type | Article | - |
dc.identifier.wosid | 000319706000004 | - |
dc.identifier.scopusid | 2-s2.0-84878715514 | - |
dc.type.rims | ART | - |
dc.citation.volume | 1 | - |
dc.citation.issue | 24 | - |
dc.citation.beginningpage | 3035 | - |
dc.citation.endingpage | 3043 | - |
dc.citation.publicationname | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.identifier.doi | 10.1039/c3tb20295j | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.contributor.nonIdAuthor | Bae, Pan-Kee | - |
dc.contributor.nonIdAuthor | Seo, Bum-Kyoung | - |
dc.contributor.nonIdAuthor | Chung, Bong-Hyun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | SUPERPARAMAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | DELIVERY-SYSTEM | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | ACID) | - |
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