DC Field | Value | Language |
---|---|---|
dc.contributor.author | Won, Byoung-Yeon | ko |
dc.contributor.author | Jung, Cheul-Hee | ko |
dc.contributor.author | Park, Ki-Soo | ko |
dc.contributor.author | Park, Hyun-Gyu | ko |
dc.date.accessioned | 2013-08-08T06:05:05Z | - |
dc.date.available | 2013-08-08T06:05:05Z | - |
dc.date.created | 2013-04-16 | - |
dc.date.created | 2013-04-16 | - |
dc.date.created | 2013-04-16 | - |
dc.date.issued | 2013-02 | - |
dc.identifier.citation | ELECTROCHEMISTRY COMMUNICATIONS, v.27, pp.100 - 103 | - |
dc.identifier.issn | 1388-2481 | - |
dc.identifier.uri | http://hdl.handle.net/10203/174875 | - |
dc.description.abstract | We have developed a novel strategy for regulating G-quadruplex formation of a DNA sequence that relies on electrochemical reduction of Pb2+ and oxidation of Pb. The DNA aptamer sequence (PW17) forms a G-quadruplex structure through interaction with Pb2+. The electrochemical reduction of Pb2+ to Pb, which accumulates on the electrode surface, brings about destruction of the G-quadruplex structure. Subsequently by applying oxidation voltage, Pb on the electrode surface goes back to Pb2+ and released Pb2+ binds again to the non-structured free PW17 sequence resulting in reformation of the G-quadruplex structure. In this manner, a PW17 DNA sequence can be reversibly switched between a very stable G-quadruplex state and a non-structured state. The results should provide insight into the development of novel mechanical DNA nanomachines that are driven by simple electrochemical processes. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | An electrochemically reversible DNA switch | - |
dc.type | Article | - |
dc.identifier.wosid | 000316159200025 | - |
dc.identifier.scopusid | 2-s2.0-84872183733 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.beginningpage | 100 | - |
dc.citation.endingpage | 103 | - |
dc.citation.publicationname | ELECTROCHEMISTRY COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.elecom.2012.11.011 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Hyun-Gyu | - |
dc.contributor.nonIdAuthor | Won, Byoung-Yeon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Nanomachine | - |
dc.subject.keywordAuthor | DNA switch | - |
dc.subject.keywordAuthor | Anodic stripping voltammetry | - |
dc.subject.keywordAuthor | G-quadruplex | - |
dc.subject.keywordAuthor | Aptamer | - |
dc.subject.keywordPlus | CLEAVING DNA | - |
dc.subject.keywordPlus | NANOMACHINE | - |
dc.subject.keywordPlus | MACHINE | - |
dc.subject.keywordPlus | WALKER | - |
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