Recent advances in immobilization methods of antibodies on solid supports

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Antibody immobilization on a solid support is an essential process for the development of most immune-based assay systems. The choice of the immobilization method greatly affects antibody-antigen interactions on the assay surface. For the past several years, numerous strategies have been reported to control antibody immobilization, mainly by directing the orientation, stability, and density of bound antibodies on different assay platforms. Here we discuss recent developments in antibody immobilization methods with a particular focus on the strengths and limitations of reported approaches, and thereby provide a useful guideline for the selection of suitable antibody coupling procedures.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2008
Language
English
Article Type
Article
Keywords

DIRECTED PROTEIN IMMOBILIZATION; SELF-ASSEMBLED MONOLAYERS; ORIENTED IMMOBILIZATION; GOLD SURFACE; MICROARRAYS; BIOSENSOR; IMMUNOSENSORS; FUNCTIONALITY; IMMUNOASSAYS; FABRICATION

Citation

ANALYST, v.133, no.6, pp.697 - 701

ISSN
0003-2654
DOI
10.1039/b800014j
URI
http://hdl.handle.net/10203/173642
Appears in Collection
CH-Journal Papers(저널논문)
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