DC Field | Value | Language |
---|---|---|
dc.contributor.author | Buermann, Frank | ko |
dc.contributor.author | Shin, Ho-Chul | ko |
dc.contributor.author | Basquin, Jerome | ko |
dc.contributor.author | Soh, Young-Min | ko |
dc.contributor.author | Gimenez-Oya, Victor | ko |
dc.contributor.author | Kim, Yeon-Gil | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.contributor.author | Gruber, Stephan | ko |
dc.date.accessioned | 2013-04-11T07:49:38Z | - |
dc.date.available | 2013-04-11T07:49:38Z | - |
dc.date.created | 2013-04-09 | - |
dc.date.created | 2013-04-09 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.citation | NATURE STRUCTURAL & MOLECULAR BIOLOGY, v.20, no.3, pp.371 - 379 | - |
dc.identifier.issn | 1545-9993 | - |
dc.identifier.uri | http://hdl.handle.net/10203/173441 | - |
dc.description.abstract | Eukaryotic structural maintenance of chromosomes (SMC)-kleisin complexes form large, ring-shaped assemblies that promote accurate chromosome segregation. Their asymmetric structural core comprises SMC heterodimers that associate with both ends of a kleisin subunit. However, prokaryotic condensin Smc-ScpAB is composed of symmetric Smc homodimers associated with the kleisin ScpA in a postulated symmetrical manner. Here, we demonstrate that Smc molecules have two distinct binding sites for ScpA. The N terminus of ScpA binds the Smc coiled coil, whereas the C terminus binds the Smc ATPase domain. We show that in Bacillus sub fills cells, an Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complexes. We define a molecular mechanism that ensures asymmetric assembly, and we conclude that the basic architecture of SMC-kleisin rings evolved before the emergence of eukaryotes. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | PROMOTES CHROMOSOME SEGREGATION | - |
dc.subject | SISTER-CHROMATID COHESION | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | BACILLUS-SUBTILIS | - |
dc.subject | ATP HYDROLYSIS | - |
dc.subject | DNA | - |
dc.subject | PROTEINS | - |
dc.subject | COMPLEX | - |
dc.subject | ARCHITECTURE | - |
dc.subject | BACTERIAL | - |
dc.title | An asymmetric SMC-kleisin bridge in prokaryotic condensin | - |
dc.type | Article | - |
dc.identifier.wosid | 000316041000020 | - |
dc.identifier.scopusid | 2-s2.0-84875165205 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 371 | - |
dc.citation.endingpage | 379 | - |
dc.citation.publicationname | NATURE STRUCTURAL & MOLECULAR BIOLOGY | - |
dc.identifier.doi | 10.1038/nsmb.2488 | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Buermann, Frank | - |
dc.contributor.nonIdAuthor | Basquin, Jerome | - |
dc.contributor.nonIdAuthor | Soh, Young-Min | - |
dc.contributor.nonIdAuthor | Gimenez-Oya, Victor | - |
dc.contributor.nonIdAuthor | Kim, Yeon-Gil | - |
dc.contributor.nonIdAuthor | Gruber, Stephan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROMOTES CHROMOSOME SEGREGATION | - |
dc.subject.keywordPlus | SISTER-CHROMATID COHESION | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | BACILLUS-SUBTILIS | - |
dc.subject.keywordPlus | ATP HYDROLYSIS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.subject.keywordPlus | BACTERIAL | - |
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