DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyung Yun | ko |
dc.contributor.author | Park, Jong-Myoung | ko |
dc.contributor.author | Jang, Yu-Sin | ko |
dc.contributor.author | Lee, Jeong-Wook | ko |
dc.contributor.author | Lee, SangYup | ko |
dc.date.accessioned | 2013-03-29T14:22:24Z | - |
dc.date.available | 2013-03-29T14:22:24Z | - |
dc.date.created | 2012-07-05 | - |
dc.date.created | 2012-07-05 | - |
dc.date.created | 2012-07-05 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | Annual Fall Meeting of KIChE 2011 | - |
dc.identifier.uri | http://hdl.handle.net/10203/171347 | - |
dc.description.abstract | A less frequently employed Escherichia coli strain W, yet possessing useful metabolic characteristics such as less acetic acid production and high L-valine tolerance, was metabolically engineered for the production of L-valine. The engineered E. coli W (ΔlacI ΔilvA) strain overexpressing the ilvBNmut, ilvCED, ygaZH and lrp genes was able to produce an impressively high concentration of 60.7 g/L L-valine by fed-batch culture in 29.5 h, resulting in a high volumetric productivity of 2.06 g/L/h. The results obtained in this study suggest that E. coli W can be a good alternative to Corynebacterium glutamicum and E. coli K-12, which have so far been the most efficient L-valine producer. Furthermore, it is expected that various bioproducts including other amino acids might be more efficiently produced by this revisited platform strain of E. coli. | - |
dc.language | English | - |
dc.publisher | 한국화학공학회 | - |
dc.title | High-level L-valine production by systematically engineered Escherichia coli W | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | Annual Fall Meeting of KIChE 2011 | - |
dc.identifier.conferencecountry | KO | - |
dc.identifier.conferencelocation | Songdo | - |
dc.contributor.localauthor | Lee, SangYup | - |
dc.contributor.nonIdAuthor | Lee, Kyung Yun | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.