DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyun Woo | ko |
dc.contributor.author | Choi, Jeonghoon | ko |
dc.contributor.author | Shin, Hyewon | ko |
dc.contributor.author | Kim, Karam | ko |
dc.contributor.author | Yang, Jinhee | ko |
dc.contributor.author | Na, Moonseok | ko |
dc.contributor.author | Choi, So Yoen | ko |
dc.contributor.author | Kang, Gil Bu | ko |
dc.contributor.author | Eom, Soo Hyun | ko |
dc.contributor.author | Kim, Hyun | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2010-03-10T08:20:43Z | - |
dc.date.available | 2010-03-10T08:20:43Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-12 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE, v.28, no.53, pp.14546 - 14556 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/10203/17081 | - |
dc.description.abstract | PSD-95 is an abundant postsynaptic density (PSD) protein involved in the formation and regulation of excitatory synapses and dendritic spines, but the underlying mechanisms are not comprehensively understood. Here we report a novel PSD-95-interacting protein Preso that regulates spine morphogenesis. Preso is mainly expressed in the brain and contains WW( domain with two conserved Trp residues), PDZ (PSD-95/Dlg/ZO-1), FERM (4.1, ezrin, radixin, and moesin), and C-terminal PDZ-binding domains. These domains associate with actin filaments, the Rac1/Cdc42 guanine nucleotide exchange factor beta Pix, phosphatidylinositol-4,5-bisphosphate, and the postsynaptic scaffolding protein PSD-95, respectively. Preso overexpression increases the density of dendritic spines in a manner requiring WW, PDZ, FERM, and PDZ-binding domains. Conversely, knockdown or dominant-negative inhibition of Preso decreases spine density, excitatory synaptic transmission, and the spine level of filamentous actin. These results suggest that Preso positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, PSD-95, and the beta Pix-based Rac1 signaling pathway. | - |
dc.description.sponsorship | This work was supported by the National Creative Research Initiative Program of the Korean Ministry of Science and Technology (E.K.) and the 21C Frontier Research and Development Program in Neuroscience of the Korean Ministry of Science and Technology (Grant M103KV010023-07K2201-02510) (H.K.). We thank the Kazusa DNA Research Institute for the KIAA0316 cDNA clone. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | SOC NEUROSCIENCE | - |
dc.subject | POSTSYNAPTIC DENSITY | - |
dc.subject | ACTIN CYTOSKELETON | - |
dc.subject | SYNAPSE FORMATION | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | EXCITATORY SYNAPSES | - |
dc.subject | ERM PROTEINS | - |
dc.subject | RHO-GTPASES | - |
dc.subject | MEMBRANE | - |
dc.subject | MORPHOLOGY | - |
dc.subject | FAMILY | - |
dc.title | Preso, A Novel PSD-95-Interacting FERM and PDZ Domain Protein That Regulates Dendritic Spine Morphogenesis | - |
dc.type | Article | - |
dc.identifier.wosid | 000262137800025 | - |
dc.identifier.scopusid | 2-s2.0-58149392098 | - |
dc.type.rims | ART | - |
dc.citation.volume | 28 | - |
dc.citation.issue | 53 | - |
dc.citation.beginningpage | 14546 | - |
dc.citation.endingpage | 14556 | - |
dc.citation.publicationname | JOURNAL OF NEUROSCIENCE | - |
dc.identifier.doi | 10.1523/JNEUROSCI.3112-08.2008 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Lee, Hyun Woo | - |
dc.contributor.nonIdAuthor | Choi, Jeonghoon | - |
dc.contributor.nonIdAuthor | Shin, Hyewon | - |
dc.contributor.nonIdAuthor | Kim, Karam | - |
dc.contributor.nonIdAuthor | Yang, Jinhee | - |
dc.contributor.nonIdAuthor | Na, Moonseok | - |
dc.contributor.nonIdAuthor | Choi, So Yoen | - |
dc.contributor.nonIdAuthor | Kang, Gil Bu | - |
dc.contributor.nonIdAuthor | Eom, Soo Hyun | - |
dc.contributor.nonIdAuthor | Kim, Hyun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | PSD-95 | - |
dc.subject.keywordAuthor | WW | - |
dc.subject.keywordAuthor | PDZ | - |
dc.subject.keywordAuthor | FERM | - |
dc.subject.keywordAuthor | actin | - |
dc.subject.keywordAuthor | spine | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY | - |
dc.subject.keywordPlus | ACTIN CYTOSKELETON | - |
dc.subject.keywordPlus | SYNAPSE FORMATION | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | EXCITATORY SYNAPSES | - |
dc.subject.keywordPlus | ERM PROTEINS | - |
dc.subject.keywordPlus | RHO-GTPASES | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | MORPHOLOGY | - |
dc.subject.keywordPlus | FAMILY | - |
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