DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Seifert, Ulrike | ko |
dc.contributor.author | Urban, Sabrina | ko |
dc.contributor.author | Truong, Kim-Thuy | ko |
dc.contributor.author | Feinstone, Stephen M. | ko |
dc.contributor.author | Rice, Charles M. | ko |
dc.contributor.author | Kloetzel, Peter-M. | ko |
dc.contributor.author | Rehermann, Barbara | ko |
dc.date.accessioned | 2009-11-30T08:19:17Z | - |
dc.date.available | 2009-11-30T08:19:17Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.citation | JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, v.27, no.12, pp.985 - 990 | - |
dc.identifier.issn | 1079-9907 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13705 | - |
dc.description.abstract | Many components of the class I antigen-processing pathway are thought to be regulated solely by interferon-gamma (IFN-gamma). Herein, we report type I IFN-mediated induction of proteasome activator (PA28) subunits alpha and beta, endoplasmic reticulum aminopeptidase 1 (ERAP1), ERAP2, and leucine aminopeptidase (LAP). This mechanism was initiated by either synthetic RNA (poly(I-C)) or by hepatitis C virus (HCV) RNA-mediated induction of type I IFN and abrogated by blocking of type I IFN. In serial liver biopsies of chimpanzees with acute HCV infection, increases in PA28 subunit and aminopeptidase mRNA levels correlated with intrahepatic type I IFN responses and preceded intrahepatic IFN-gamma responses by several weeks. Thus, viral RNA-induced type I IFN regulates the antigen-processing machinery early during viral infection and prior to IFN-gamma response. This mechanism may contribute to the high effectiveness of type I IFN-based therapies if administered early during acute HCV infection. | - |
dc.description.sponsorship | This study was supported in part by the NIH, NIDDK, and CBER FDA intramural research programs, by grant SFB 421 from the Deutsche Forschungsgemeinschaft, Bonn, Germany, to U.S. and P.M.K.,and by U.S. Public Health Service grant CA85883-01 to C.M.R. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | MARY ANN LIEBERT INC | - |
dc.subject | MHC CLASS-I | - |
dc.subject | CELLULAR IMMUNE-RESPONSES | - |
dc.subject | CD8(+) T-CELLS | - |
dc.subject | VIRAL CLEARANCE | - |
dc.subject | GAMMA | - |
dc.subject | IMMUNOPROTEASOMES | - |
dc.subject | PERSISTENCE | - |
dc.subject | GENERATION | - |
dc.subject | PEPTIDES | - |
dc.subject | EPITOPES | - |
dc.title | Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver | - |
dc.type | Article | - |
dc.identifier.wosid | 000252187000002 | - |
dc.identifier.scopusid | 2-s2.0-38049039851 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 985 | - |
dc.citation.endingpage | 990 | - |
dc.citation.publicationname | JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | - |
dc.identifier.doi | 10.1089/jir.2007.0039 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Seifert, Ulrike | - |
dc.contributor.nonIdAuthor | Urban, Sabrina | - |
dc.contributor.nonIdAuthor | Truong, Kim-Thuy | - |
dc.contributor.nonIdAuthor | Feinstone, Stephen M. | - |
dc.contributor.nonIdAuthor | Rice, Charles M. | - |
dc.contributor.nonIdAuthor | Kloetzel, Peter-M. | - |
dc.contributor.nonIdAuthor | Rehermann, Barbara | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MHC CLASS-I | - |
dc.subject.keywordPlus | CELLULAR IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | VIRAL CLEARANCE | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | IMMUNOPROTEASOMES | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | EPITOPES | - |
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