DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, JB | ko |
dc.contributor.author | Chun, KW | ko |
dc.contributor.author | Yoon, JJ | ko |
dc.contributor.author | Park, TG | ko |
dc.date.accessioned | 2009-11-25T03:13:43Z | - |
dc.date.available | 2009-11-25T03:13:43Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-10 | - |
dc.identifier.citation | MACROMOLECULAR BIOSCIENCE, v.4, no.10, pp.957 - 962 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13315 | - |
dc.description.abstract | Chemically crosslinked biodegradable hydrogels based on di-acrylated Pluronic F-127 tri-block copolymer were prepared by a photopolymerization method. Poly(lactic acid-co-glycolic acid) (PLGA) microspheres were physically entrapped within the Pluronic hydrogel in order to modulate the local pH environment by acidic degradation by-products of PLGA microspheres. The PLGA microspheres were slowly degraded to create an acidic microenvironment, which facilitated the cleavage of an acid-labile ester-linkage in the biodegradable Pluronic hydrogel network. The presence of PLGA microspheres accelerated the degradation of the Pluronic hydrogel and enhanced the protein release rate when protein was loaded in the hydrogel. | - |
dc.description.sponsorship | Center for Advanced Functional Polymers, KAISTand from the Korea Science and Engineering Foundation, Korea | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Wiley-Blackwell | - |
dc.subject | DRUG-DELIVERY SYSTEMS | - |
dc.subject | BLOCK-COPOLYMERS | - |
dc.subject | POLY(D,L-LACTIC-CO-GLYCOLIC ACID) | - |
dc.subject | FUMARATE) HYDROGELS | - |
dc.subject | CONTROLLED-RELEASE | - |
dc.subject | BIOCOMPATIBILITY | - |
dc.subject | TEMPERATURE | - |
dc.subject | BEHAVIOR | - |
dc.title | Controlling degradation of acid-hydrolyzable pluronic irilydrogels by physical entrapment of poly(lactic acid-co-glycolic acid) microspheres | - |
dc.type | Article | - |
dc.identifier.wosid | 000225004100007 | - |
dc.identifier.scopusid | 2-s2.0-8744282349 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 957 | - |
dc.citation.endingpage | 962 | - |
dc.citation.publicationname | MACROMOLECULAR BIOSCIENCE | - |
dc.identifier.doi | 10.1002/mabi.200400073 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, TG | - |
dc.contributor.nonIdAuthor | Lee, JB | - |
dc.contributor.nonIdAuthor | Chun, KW | - |
dc.contributor.nonIdAuthor | Yoon, JJ | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | biodegradable | - |
dc.subject.keywordAuthor | pluronic hydrogels | - |
dc.subject.keywordAuthor | PLGA microspheres | - |
dc.subject.keywordAuthor | photopolymerization | - |
dc.subject.keywordAuthor | protein delivery | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEMS | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | POLY(D,L-LACTIC-CO-GLYCOLIC ACID) | - |
dc.subject.keywordPlus | FUMARATE) HYDROGELS | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | BIOCOMPATIBILITY | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | BEHAVIOR | - |
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