Synthesis of novel biodegradable cationic dendrimers

Cited 13 time in webofscience Cited 14 time in scopus
  • Hit : 333
  • Download : 7
DC FieldValueLanguage
dc.contributor.authorLee, Jin-Seongko
dc.contributor.authorHuh, Juneko
dc.contributor.authorAhn, Cheol-Heeko
dc.contributor.authorLee, Minhyungko
dc.contributor.authorPark, Tae Gwanko
dc.date.accessioned2009-11-25T02:44:06Z-
dc.date.available2009-11-25T02:44:06Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2006-09-
dc.identifier.citationMACROMOLECULAR RAPID COMMUNICATIONS, v.27, no.18, pp.1608 - 1614-
dc.identifier.issn1022-1336-
dc.identifier.urihttp://hdl.handle.net/10203/13306-
dc.description.abstractDendrons and dendrimers with cationic amino groups at their periphery were successfully synthesized up to the third and second generation, respectively. The results obtained by (1)H NMR spectroscopy and gel permeation chromatography analysis supported the formation of the targeted dendrons and dendrimers. The dendrons were grown via ester linkages, which endowed them with biodegradability in D(2)O at 37 degrees C. The degradation rate depends upon the steric hindrance and reactivity caused by the bulkiness and compact structure of the dendrons. All of the synthesized dendrons were degraded within a month, while 60% of the ester groups in the sterically crowded dendrimers were degraded over the same time period. The cytotoxicity of the dendrons was evaluated by the MTT assay on a 293T cell line which indicated that the obtained dendrons were completely non-toxic. These non-toxic, biodegradable cationic dendrons and dendrimers are believed to have potential applications in the biomedical field.-
dc.description.sponsorshipthe Ministry of Science and Technology (No. M10414030002- 05N1403-00200), Korea.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectDENDRITIC MACROMOLECULES-
dc.subjectBIOMEDICAL APPLICATIONS-
dc.subjectPAMAM DENDRIMERS-
dc.subjectDRUG-DELIVERY-
dc.subjectPOLYMERS-
dc.subjectSYSTEM-
dc.titleSynthesis of novel biodegradable cationic dendrimers-
dc.typeArticle-
dc.identifier.wosid000241200800015-
dc.identifier.scopusid2-s2.0-33749562616-
dc.type.rimsART-
dc.citation.volume27-
dc.citation.issue18-
dc.citation.beginningpage1608-
dc.citation.endingpage1614-
dc.citation.publicationnameMACROMOLECULAR RAPID COMMUNICATIONS-
dc.identifier.doi10.1002/marc.200600393-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorLee, Jin-Seong-
dc.contributor.nonIdAuthorHuh, June-
dc.contributor.nonIdAuthorAhn, Cheol-Hee-
dc.contributor.nonIdAuthorLee, Minhyung-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorbiodegradable-
dc.subject.keywordAuthordendrimers-
dc.subject.keywordAuthordendrons-
dc.subject.keywordAuthornon-toxicity-
dc.subject.keywordAuthorpolyesters-
dc.subject.keywordPlusDENDRITIC MACROMOLECULES-
dc.subject.keywordPlusBIOMEDICAL APPLICATIONS-
dc.subject.keywordPlusPAMAM DENDRIMERS-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusPOLYMERS-
dc.subject.keywordPlusSYSTEM-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 13 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0