DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, JH | ko |
dc.contributor.author | Kim, SH | ko |
dc.contributor.author | Kim, SW | ko |
dc.contributor.author | Park, TG | ko |
dc.date.accessioned | 2009-11-24T05:16:43Z | - |
dc.date.available | 2009-11-24T05:16:43Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-11 | - |
dc.identifier.citation | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.16, no.11, pp.1409 - 1419 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13199 | - |
dc.description.abstract | A tumor-targeting antisense oligodeoxynucleotide (ODN) delivery system based on polyelectrolyte complex (PEC) micelles is demonstrated. ODN-PEG-folic acid (ODN-PEG-FA) was synthesized using a heterofunctional PEG linker. The PEC micelles for the targeted ODN delivery to tumor cells were produced by ionic interactions between the ODN-PEG-FA and polyethylenimine (PEI). The in vivo targeting properties of the PEC micelles were assessed using a mouse tumor model. The size of ODN-PEG-FA/PEI PEC micelles was 92.3 nm with a relatively narrow distribution. Cellular uptake of the ODN-PEG-FA/PEI PEC micelles by folic acid receptor over-expressing cells (KB) was greatly enhanced compared to that of ODN-PEG/PEI PEC micelles. When the ODN-PEG-FA/PEI PEC micelles were systemically administered to the mice bearing KB cell xenograft tumor, ODN was accumulated to the solid tumor in a target specific manner. This study suggests that the PEC micelles with a receptor-recognizable targeting ligand on the surface have potential for passive and active targeted delivery of ODN drugs to cancer cells. | - |
dc.description.sponsorship | the Ministry of Science and Technology, South Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Vsp Bv | - |
dc.subject | BIODEGRADABLE POLYMERIC MICELLES | - |
dc.subject | ANTISENSE OLIGONUCLEOTIDE | - |
dc.subject | GENE DELIVERY | - |
dc.subject | POLYETHYLENIMINE/DNA COMPLEXES | - |
dc.subject | MEDIATED DELIVERY | - |
dc.subject | BLOCK-COPOLYMER | - |
dc.subject | FOLATE | - |
dc.subject | CELLS | - |
dc.subject | CONJUGATE | - |
dc.subject | RECEPTOR | - |
dc.title | In vivo tumor targeting of ODN-PEG-folic acid/PEI polyelectrolyte complex micelles | - |
dc.type | Article | - |
dc.identifier.wosid | 000233916200006 | - |
dc.identifier.scopusid | 2-s2.0-33644828226 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 1409 | - |
dc.citation.endingpage | 1419 | - |
dc.citation.publicationname | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.identifier.doi | 10.1163/156856205774472335 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, TG | - |
dc.contributor.nonIdAuthor | Jeong, JH | - |
dc.contributor.nonIdAuthor | Kim, SH | - |
dc.contributor.nonIdAuthor | Kim, SW | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | folic acid | - |
dc.subject.keywordAuthor | tumor targeting | - |
dc.subject.keywordAuthor | oligodeoxynucleotide | - |
dc.subject.keywordAuthor | micelles | - |
dc.subject.keywordAuthor | poly(ethylene glycol) | - |
dc.subject.keywordPlus | BIODEGRADABLE POLYMERIC MICELLES | - |
dc.subject.keywordPlus | ANTISENSE OLIGONUCLEOTIDE | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | POLYETHYLENIMINE/DNA COMPLEXES | - |
dc.subject.keywordPlus | MEDIATED DELIVERY | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER | - |
dc.subject.keywordPlus | FOLATE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CONJUGATE | - |
dc.subject.keywordPlus | RECEPTOR | - |
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