DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, S. B. | ko |
dc.contributor.author | Chae, G. W. | ko |
dc.contributor.author | Lee, J. | ko |
dc.contributor.author | Park, J. | ko |
dc.contributor.author | Tak, H. | ko |
dc.contributor.author | Chung, Jae Hoon | ko |
dc.contributor.author | Park, T. G. | ko |
dc.contributor.author | Ahn, J. K. | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.date.accessioned | 2009-11-23T07:53:05Z | - |
dc.date.available | 2009-11-23T07:53:05Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-05 | - |
dc.identifier.citation | CELL DEATH AND DIFFERENTIATION, v.14, no.5, pp.982 - 991 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13135 | - |
dc.description.abstract | We propose a biochemical mechanism for the negative role of Notch signaling on p53 transactivation function. Expression of the intracellular domain of human Notch1 (Notch1- IC) inhibits the expression of p53-responsive genes p21, mdm2, and bax in HCT116 p53(-/-) cells. Furthermore, Notch1-IC expression inhibits the phosphorylation of ectopically expressed p53 in HCT116 p53(-/ -) cells as well as the phosphorylation of endogenous p53 in UV-treated HCT116 p53(+)/(+) cells. Transcriptional downregulation of p53- responsive genes by Notch1-IC was confirmed both by chromatin immunoprecipitation assay and Northern blot analysis. We found the intracellular interaction between Notch1-IC and p53 in HCT116 p53(+/+) cells and suggest that activated Notch1 interaction with p53 is an important cellular event for the inhibition of p53-dependent transactivation. The N-terminal fragment of Notch1-IC, which can interacts with p53, inhibits p53 phosphorylation and represses p53 transactivation. In addition, Notch signaling downregulated p53-dependent apoptosis induced by UV irradiation. | - |
dc.description.sponsorship | Korean National Cancer Control Program, Ministry of Health and Welfare (0220150-3); the Korea Science and Engineering Foundation (2004-01885); and the Korea Research Foundation (KRF-2003-015- C00534 and KRF-2005-070-C00105). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group | - |
dc.subject | DNA-BINDING FUNCTION | - |
dc.subject | TUMOR-SUPPRESSOR | - |
dc.subject | CHROMOSOMAL TRANSLOCATIONS | - |
dc.subject | NEOPLASTIC TRANSFORMATION | - |
dc.subject | LYMPHOBLASTIC NEOPLASMS | - |
dc.subject | GROWTH ARREST | - |
dc.subject | APOPTOSIS | - |
dc.subject | EXPRESSION | - |
dc.subject | PATHWAY | - |
dc.subject | CELLS | - |
dc.title | Activated Notch1 interacts with p53 to inhibit its phosphorylation and transactivation | - |
dc.type | Article | - |
dc.identifier.wosid | 000245851300011 | - |
dc.identifier.scopusid | 2-s2.0-34247356578 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 982 | - |
dc.citation.endingpage | 991 | - |
dc.citation.publicationname | CELL DEATH AND DIFFERENTIATION | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Chung, Jae Hoon | - |
dc.contributor.localauthor | Park, T. G. | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Kim, S. B. | - |
dc.contributor.nonIdAuthor | Chae, G. W. | - |
dc.contributor.nonIdAuthor | Lee, J. | - |
dc.contributor.nonIdAuthor | Park, J. | - |
dc.contributor.nonIdAuthor | Tak, H. | - |
dc.contributor.nonIdAuthor | Ahn, J. K. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | Notch | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | phosphorylation | - |
dc.subject.keywordAuthor | tumor suppressor | - |
dc.subject.keywordPlus | DNA-BINDING FUNCTION | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | CHROMOSOMAL TRANSLOCATIONS | - |
dc.subject.keywordPlus | NEOPLASTIC TRANSFORMATION | - |
dc.subject.keywordPlus | LYMPHOBLASTIC NEOPLASMS | - |
dc.subject.keywordPlus | GROWTH ARREST | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CELLS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.