DC Field | Value | Language |
---|---|---|
dc.contributor.author | TAE GWAN PARK | ko |
dc.contributor.author | Lee, H | ko |
dc.contributor.author | Kim, TH | ko |
dc.date.accessioned | 2009-11-23T05:00:02Z | - |
dc.date.available | 2009-11-23T05:00:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-06 | - |
dc.identifier.citation | BIOMATERIALS, v.23, no.11, pp.2311 - 2317 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13107 | - |
dc.description.abstract | Recombinant human epidermal growth factor (rhEGF) was conjugated with polyethylene glycol (PEG) to improve its physical stability during microcticapsulation in biodegradable poly(lactic-co-glycolic acid) microspheres. rhEGF was conjugated with N-hydroxysuccimide (NHS)-derivatized methoxy-PEG (mPEG) of MW 2000 and 5000 under various reaction conditions to optimize the extent of pegylation. Pegylated rhEGF showed much enhanced physical stability against homogenization. Pegylated rhEGF was encapsulated in PLGA microspheres by a double emulsion solvent evaporation method to achieve a sustained release. Pegaylated rhEGF exhibited a tri-phasic release profile with a reduced initial burst, compared with unpegylated rhEGF. This study demonstrated that protein pegylation enhanced physical stability of protein and could be a good approach to achieve a sustained protein release profile from biodegradable microspheres. (C) 2002 Elsevier Science Ltd. All rights reserved. | - |
dc.description.sponsorship | the Center for Advanced Functional Polymers, KAIST, Korea | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Elsevier Sci Ltd | - |
dc.subject | PROTEIN STABILITY | - |
dc.subject | GLYCOL) MICROSPHERES | - |
dc.subject | DEGRADATION | - |
dc.title | Pegylated Recombinant Human Epidermal Growth Factor (rhEGF) for Sustained Release from Biodegradable PLGA Microspheres | - |
dc.type | Article | - |
dc.identifier.wosid | 000175259900005 | - |
dc.identifier.scopusid | 2-s2.0-0036128917 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 2311 | - |
dc.citation.endingpage | 2317 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | TAE GWAN PARK | - |
dc.contributor.nonIdAuthor | Lee, H | - |
dc.contributor.nonIdAuthor | Kim, TH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | recombinant human epidermal growth factor (rhEGF) | - |
dc.subject.keywordAuthor | pegylation | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | microspheres | - |
dc.subject.keywordAuthor | stability | - |
dc.subject.keywordPlus | PROTEIN STABILITY | - |
dc.subject.keywordPlus | GLYCOL) MICROSPHERES | - |
dc.subject.keywordPlus | DEGRADATION | - |
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