Pegylated Recombinant Human Epidermal Growth Factor (rhEGF) for Sustained Release from Biodegradable PLGA Microspheres

Cited 56 time in webofscience Cited 0 time in scopus
  • Hit : 372
  • Download : 139
DC FieldValueLanguage
dc.contributor.authorTAE GWAN PARKko
dc.contributor.authorLee, Hko
dc.contributor.authorKim, THko
dc.date.accessioned2009-11-23T05:00:02Z-
dc.date.available2009-11-23T05:00:02Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2002-06-
dc.identifier.citationBIOMATERIALS, v.23, no.11, pp.2311 - 2317-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10203/13107-
dc.description.abstractRecombinant human epidermal growth factor (rhEGF) was conjugated with polyethylene glycol (PEG) to improve its physical stability during microcticapsulation in biodegradable poly(lactic-co-glycolic acid) microspheres. rhEGF was conjugated with N-hydroxysuccimide (NHS)-derivatized methoxy-PEG (mPEG) of MW 2000 and 5000 under various reaction conditions to optimize the extent of pegylation. Pegylated rhEGF showed much enhanced physical stability against homogenization. Pegylated rhEGF was encapsulated in PLGA microspheres by a double emulsion solvent evaporation method to achieve a sustained release. Pegaylated rhEGF exhibited a tri-phasic release profile with a reduced initial burst, compared with unpegylated rhEGF. This study demonstrated that protein pegylation enhanced physical stability of protein and could be a good approach to achieve a sustained protein release profile from biodegradable microspheres. (C) 2002 Elsevier Science Ltd. All rights reserved.-
dc.description.sponsorshipthe Center for Advanced Functional Polymers, KAIST, Koreaen
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherElsevier Sci Ltd-
dc.subjectPROTEIN STABILITY-
dc.subjectGLYCOL) MICROSPHERES-
dc.subjectDEGRADATION-
dc.titlePegylated Recombinant Human Epidermal Growth Factor (rhEGF) for Sustained Release from Biodegradable PLGA Microspheres-
dc.typeArticle-
dc.identifier.wosid000175259900005-
dc.identifier.scopusid2-s2.0-0036128917-
dc.type.rimsART-
dc.citation.volume23-
dc.citation.issue11-
dc.citation.beginningpage2311-
dc.citation.endingpage2317-
dc.citation.publicationnameBIOMATERIALS-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorTAE GWAN PARK-
dc.contributor.nonIdAuthorLee, H-
dc.contributor.nonIdAuthorKim, TH-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorrecombinant human epidermal growth factor (rhEGF)-
dc.subject.keywordAuthorpegylation-
dc.subject.keywordAuthorPLGA-
dc.subject.keywordAuthormicrospheres-
dc.subject.keywordAuthorstability-
dc.subject.keywordPlusPROTEIN STABILITY-
dc.subject.keywordPlusGLYCOL) MICROSPHERES-
dc.subject.keywordPlusDEGRADATION-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 56 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0