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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

A new antisense oligonucleotide delivery system based on self-assembled ODN–PEG hybrid conjugate micelles

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dc.contributor.authorJeong, Ji Hoonko
dc.contributor.authorKim, Sung Wanko
dc.contributor.authorPark, Tae Gwanko
dc.date.accessioned2009-11-23T02:58:38Z-
dc.date.available2009-11-23T02:58:38Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-12-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, v.93, no.2, pp.183 - 191-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/10203/13100-
dc.description.abstractThe conjugate of antisense c-raf oligonucleotide (ODN) and poly(ethylene glycol) (PEG) was synthesized for intracellular ODN delivery. When combined with polyethylenimine (PEI), the ODN-PEG conjugate self-associated to form polyelectrolyte complex micelles in aqueous solution. The effective hydrodynamic diameter of the micelles was ca. 70 nm with a narrow size distribution. Flow cytometry analysis indicated that the cellular uptake of the micelles by A2780 cells was much higher than that of ODN alone. The micelles also showed a superior antiproliferative activity against ovarian cancer cells in vitro and in vivo. (C) 2003 Elsevier B.V. All rights reserved.-
dc.description.sponsorshipthe Ministry of Science and Technology (M10214000117-02b1500- 02110), from National Cancer Center (02-3-150), from the Ministry of Information and Communication (IMT-2000-B3-2), Republic of Korea.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherElsevier Science Bv-
dc.subjectPOLYION COMPLEX MICELLES-
dc.subjectC-RAF KINASE-
dc.subjectBLOCK-COPOLYMER-
dc.subjectNUCLEASE RESISTANCE-
dc.subjectPOLYETHYLENE-GLYCOL-
dc.subjectPOLYMERIC MICELLES-
dc.subjectFUSOGENIC PEPTIDE-
dc.subjectOVARIAN-CANCER-
dc.subjectPLASMID DNA-
dc.subjectIN-VIVO-
dc.titleA new antisense oligonucleotide delivery system based on self-assembled ODN–PEG hybrid conjugate micelles-
dc.typeArticle-
dc.identifier.wosid000187625400009-
dc.identifier.scopusid2-s2.0-0242494161-
dc.type.rimsART-
dc.citation.volume93-
dc.citation.issue2-
dc.citation.beginningpage183-
dc.citation.endingpage191-
dc.citation.publicationnameJOURNAL OF CONTROLLED RELEASE-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorJeong, Ji Hoon-
dc.contributor.nonIdAuthorKim, Sung Wan-
dc.type.journalArticleArticle; Proceedings Paper-
dc.subject.keywordAuthorODN-
dc.subject.keywordAuthorPEG-
dc.subject.keywordAuthormicelles-
dc.subject.keywordAuthorconjugate-
dc.subject.keywordAuthordelivery-
dc.subject.keywordPlusPOLYION COMPLEX MICELLES-
dc.subject.keywordPlusC-RAF KINASE-
dc.subject.keywordPlusBLOCK-COPOLYMER-
dc.subject.keywordPlusNUCLEASE RESISTANCE-
dc.subject.keywordPlusPOLYETHYLENE-GLYCOL-
dc.subject.keywordPlusPOLYMERIC MICELLES-
dc.subject.keywordPlusFUSOGENIC PEPTIDE-
dc.subject.keywordPlusOVARIAN-CANCER-
dc.subject.keywordPlusPLASMID DNA-
dc.subject.keywordPlusIN-VIVO-
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