DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyukjin | ko |
dc.contributor.author | Jeong, Yongho | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-20T06:48:57Z | - |
dc.date.available | 2009-11-20T06:48:57Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.citation | BIOMACROMOLECULES, v.8, no.12, pp.3705 - 3711 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13013 | - |
dc.description.abstract | Shell cross-linked hollow polyelectrolyte microcapsules composed of hyaluronic acid (HA) and poly-L-lysine (PLL) were prepared by layer-by-layer (LBL) adsorption and subsequent core removal by a reductive agent. Disulfide cross-linked HA microgels were used as template core. materials for the LBL deposition on the surface and removed by treatment of dithiothreitol at neutral pH condition. HA/PLL polyelectrolyte multilayers on the shell were chemically cross-linked via carbodiimide chemistry, and their physicochemical properties and drug release behaviors were investigated. Shell cross-linked HA/PLL polyelectrolyte microcapsules exhibited far enhanced physical stability against freeze-thaw cycles and acidic pH conditions compared to the un-cross-linked ones. The cross-linked HA/PLL multilayer shell also demonstrated pH responsive permeability, which became more permeable at low pH than at,neutral pH. When bovine serum albumin (BSA), as a model protein drug, was loaded inside using the pH-dependent permeability, BSA release profiles from the microcapsules could be readily modulated by varying medium pH values or adding an HA digesting enzyme (hyaluronidase) in the incubation medium. | - |
dc.description.sponsorship | National Research Laboratory grant from the Ministry of Science and Technology, Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | WEAK POLYELECTROLYTES | - |
dc.subject | MULTILAYER MICROCAPSULES | - |
dc.subject | RESPONSIVE PROPERTIES | - |
dc.subject | CAPSULES | - |
dc.subject | ENCAPSULATION | - |
dc.subject | PERMEABILITY | - |
dc.subject | DELIVERY | - |
dc.subject | RELEASE | - |
dc.subject | MICROSPHERES | - |
dc.subject | NANOCAPSULES | - |
dc.title | Shell cross-linked hyaluronic acid/polylysine layer-by-layer polyelectrolyte microcapsules prepared by removal of reducible hyaluronic acid microgel cores | - |
dc.type | Article | - |
dc.identifier.wosid | 000251547600004 | - |
dc.identifier.scopusid | 2-s2.0-38049032353 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 3705 | - |
dc.citation.endingpage | 3711 | - |
dc.citation.publicationname | BIOMACROMOLECULES | - |
dc.identifier.doi | 10.1021/bm700854j | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Lee, Hyukjin | - |
dc.contributor.nonIdAuthor | Jeong, Yongho | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | WEAK POLYELECTROLYTES | - |
dc.subject.keywordPlus | MULTILAYER MICROCAPSULES | - |
dc.subject.keywordPlus | RESPONSIVE PROPERTIES | - |
dc.subject.keywordPlus | CAPSULES | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | NANOCAPSULES | - |
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