siRNA Conjugate Delivery Systems
Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and their gene silencing efficiencies were tested in vitro and in vivo. In this review, recent developments of siRNA bioconjugates are summarized.
- Publisher
- Amer Chemical Soc
- Issue Date
- 2009-11
- Language
- English
- Article Type
- Review
- Keywords
POLYELECTROLYTE COMPLEX MICELLES; CELL-PENETRATING PEPTIDES; SMALL INTERFERING RNA; POLY(ETHYLENE GLYCOL)-SIRNA CONJUGATE; TAT-DEPENDENT TRANSACTIVATION; CATIONIC FUSOGENIC PEPTIDE; CULTURED-MAMMALIAN-CELLS; INNATE IMMUNE-RESPONSE; TARGETING IN-VIVO; INTRACELLULAR DELIVERY
- Citation
BIOCONJUGATE CHEMISTRY, v.20, no.1, pp.5 - 14
- ISSN
- 1043-1802
- Appears in Collection
- BS-Journal Papers(저널논문)
- Files in This Item
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