This study is to investigate material flow and load predictions due to different interface conditions between dies and the workpiece for non-isothermal Equal Channel Angular Extrusion (ECAE) process of pure titanium CP-Ti Gr-1 alloy. The change of friction conditions was carefully investigated in terms of variation of load requirements at the beginning stage of deformation and remeshing. In order to validate the numerical results obtained, finite element simulation results were compared with the experimental data. The current investigation clearly showed the importance of proper handling of friction conditions to improve the solution accuracy especially for the ECAE process simulations. The approach will be beneficial in understanding the deformation mechanics and determining the load requirements for the ECAE with the larger specimen for industrial applications to obtain ultra-fine-grained bulk materials.