DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sun Hwa | ko |
dc.contributor.author | Jeong, Ji Hoon | ko |
dc.contributor.author | Lee, Soo Hyeon | ko |
dc.contributor.author | Kim, Sung Wan | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-11T01:04:55Z | - |
dc.date.available | 2009-11-11T01:04:55Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.129, no.2, pp.107 - 116 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/12383 | - |
dc.description.abstract | For efficient cancer therapy, small interfering RNA (siRNA) should be stably and efficiently delivered into the target tissue and readily taken up by cancer cells. To address these needs, a polyelectrolyte complex (PEC) micelle-based siRNA delivery system was developed for anti-angiogenic gene therapy. The interaction between poly(ethylene glycol) (PEG)-conjugated vascular endothelial growth factor siRNA (VEGF siRNA-PEG) and polyethylenimine (PEI) led to the spontaneous formation of nanoscale polyelectrolyte complex micelles (VEGF siRNA-PEG/PEI PEC micelles), having a characteristic siRNA/PEI PEC inner core with a surrounding PEG shell layer. Intravenous as well as intraturnoral administration of the PEC micelles significantly inhibited VEGF expression at the tumor tissue and suppressed tumor growth in an animal tumor model without showing any detectable inflammatory responses in mice. Upon examination of the PEC micelle distribution and in vivo optical imaging following intravenously injection, enhanced accumulation of the PEC micelles was also observed in the tumor region. This study demonstrates the feasibility of using PEC micelles as a potential carrier for therapeutic siRNAs in local and systemic treatment of cancer. (C) 2008 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | Ministry of Science and Technology (F104AA010002-07A0101-00210), the Ministry of Health andWelfare (A04-0041-B21004-07M4-00040B), and the National Cancer Center (0620240-1), Korea, and from the National Institute of Health (CA107070), USA. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Elsevier Science Bv | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | CATIONIC FUSOGENIC PEPTIDE | - |
dc.subject | SMALL INTERFERING RNA | - |
dc.subject | DOUBLE-STRANDED-RNA | - |
dc.subject | IN-VIVO | - |
dc.subject | ANTISENSE OLIGONUCLEOTIDE | - |
dc.subject | SYNTHETIC SIRNA | - |
dc.subject | GENE-THERAPY | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | THIOPROPIONATE LINKAGE | - |
dc.title | Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000257959400007 | - |
dc.identifier.scopusid | 2-s2.0-46549085779 | - |
dc.type.rims | ART | - |
dc.citation.volume | 129 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 107 | - |
dc.citation.endingpage | 116 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.identifier.doi | 10.1016/j.jconrel.2008.03.008 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Kim, Sun Hwa | - |
dc.contributor.nonIdAuthor | Jeong, Ji Hoon | - |
dc.contributor.nonIdAuthor | Lee, Soo Hyeon | - |
dc.contributor.nonIdAuthor | Kim, Sung Wan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | vascular endothelial growth factor | - |
dc.subject.keywordAuthor | siRNA delivery | - |
dc.subject.keywordAuthor | anti-angiogenesis | - |
dc.subject.keywordAuthor | polyelectrolyte complex micelles | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | CATIONIC FUSOGENIC PEPTIDE | - |
dc.subject.keywordPlus | SMALL INTERFERING RNA | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ANTISENSE OLIGONUCLEOTIDE | - |
dc.subject.keywordPlus | SYNTHETIC SIRNA | - |
dc.subject.keywordPlus | GENE-THERAPY | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | THIOPROPIONATE LINKAGE | - |
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