DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, SH | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-10T04:56:21Z | - |
dc.date.available | 2009-11-10T04:56:21Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-03 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.311, no.1-2, pp.223 - 228 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | http://hdl.handle.net/10203/12339 | - |
dc.description.abstract | A new formulation method was developed for preparing poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with recombinant human granulocyte colony-stimulating factor (rhG-CSF). Lyophilized rhG-CSF powder and PLGA polymer were directly co-dissolved in a single organic phase, and the resulting solution was dispersed into an aqueous Solution. PLGA nanoparticles encapsulating rhG-CSF were produced by a spontaneous emulsion/solvent diffusion method. In this manner, rhG-CSF was molecularly dissolved in the polymer phase. Release profile of rhG-CSF from PLGA nanoparticles was compared with those from two kinds of PLGA microparticles which were separately prepared by either single oil-in-water (O/W) or double water-in-oil-in-water (W/O/W) emulsion technique. The sizes of rhG-CSF loaded nanoparticles, O/W microparticles, and W/O/W microparticles were about 257 nm, 4.7 mu m, and 4.3 mu m, respectively. For rhG-CSF nanoparticles,about 90% of encapsulated rhG-CSF was released out in a sustained manner from PLGA nanoparticles over a 1 week period, but for rhG-CSF microparticles, only about 20% of rhG-CSF Could be released out during the same period. Reversed phase and size exclusion chromatograms revealed that the structural integrity of released rhG-CSF from nanoparticles was nearly intact, compared to that of native rhG-CSF. (c) 2005 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | the Ministry of Health and Welfare, Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | POLY(D,L-LACTIC-CO-GLYCOLIC ACID) MICROSPHERES | - |
dc.subject | COLONY-STIMULATING FACTOR | - |
dc.subject | HUMAN GROWTH-HORMONE | - |
dc.subject | CONTROLLED DELIVERY | - |
dc.subject | RELEASE MECHANISM | - |
dc.subject | ORGANIC-SOLVENTS | - |
dc.subject | PROTEIN RELEASE | - |
dc.subject | STABILITY | - |
dc.subject | MICROPARTICLES | - |
dc.subject | MICROENCAPSULATION | - |
dc.title | G-CSF loaded biodegradable PLGA nanoparticles prepared by a single oil-in-water emulsion method | - |
dc.type | Article | - |
dc.identifier.wosid | 000236526600030 | - |
dc.identifier.scopusid | 2-s2.0-33644625226 | - |
dc.type.rims | ART | - |
dc.citation.volume | 311 | - |
dc.citation.issue | 1-2 | - |
dc.citation.beginningpage | 223 | - |
dc.citation.endingpage | 228 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.identifier.doi | 10.1016/j.ijpharm.2005.12.023 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Choi, SH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | rhG-CSF | - |
dc.subject.keywordAuthor | biodegradable | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordPlus | POLY(D,L-LACTIC-CO-GLYCOLIC ACID) MICROSPHERES | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | HUMAN GROWTH-HORMONE | - |
dc.subject.keywordPlus | CONTROLLED DELIVERY | - |
dc.subject.keywordPlus | RELEASE MECHANISM | - |
dc.subject.keywordPlus | ORGANIC-SOLVENTS | - |
dc.subject.keywordPlus | PROTEIN RELEASE | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | MICROENCAPSULATION | - |
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