DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, KC | ko |
dc.contributor.author | Kim, BS | ko |
dc.contributor.author | Kim, JH | ko |
dc.contributor.author | Park, TG | ko |
dc.contributor.author | Do Nam, J | ko |
dc.contributor.author | Lee, DS | ko |
dc.date.accessioned | 2009-11-10T04:48:57Z | - |
dc.date.available | 2009-11-10T04:48:57Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-05 | - |
dc.identifier.citation | POLYMER, v.46, no.11, pp.3801 - 3808 | - |
dc.identifier.issn | 0032-3861 | - |
dc.identifier.uri | http://hdl.handle.net/10203/12337 | - |
dc.description.abstract | A regular and well-interconnected macroporous (from 50 to 200 μ m) poly(D,L-lactic acid-co-glycolic acid) (PLGA) scaffold was fabricated by means of the thermally induced phase separation (TIPS) method. Poly(L-lactic acid) (PLLA) was blended with PLGA to increase the viscosity of polymer solution; a block copolymer of poly(ethylene glycol) (PEG) with PLGA was added as a surfactant to decrease the interfacial tension between the polymer-rich and polymer-lean phases. The effect of TIPS parameters including the concentration of diblock copolymer and PLGA/PLLA ratio was also studied. The cloud-point curve shifted to higher temperatures with both increasing the PLLA composition in the PLGA/PLLA blend and the PEG contents in the additives (PEG itself and PEG-PLGA diblocks). This shifting to higher temperature increases the quenching depth during phase separation. Addition of a PEG-PLGA diblock copolymer (0.5 wt% in solution) to the PLGA/PLLA (1/1) blend polymer in a dioxane/water solution stabilized the morphology development during TIPS with respect to interconnection and macropores, and avoided segregation or sedimentation in the late stage. © 2005 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | the Korea Research Foundation Grant (KRF-2004-005-D00070). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Elsevier Sci Ltd | - |
dc.subject | BIODEGRADABLE POLYMER SCAFFOLDS | - |
dc.subject | CELL TRANSPLANTATION | - |
dc.subject | POLY(L-LACTIDE) SCAFFOLD | - |
dc.subject | TERNARY-SYSTEM | - |
dc.subject | DYNAMICS | - |
dc.title | A facile preparation of highly interconnected macroporous PLGA scaffolds by liquid-liquid phase separation II | - |
dc.type | Article | - |
dc.identifier.wosid | 000229051200030 | - |
dc.identifier.scopusid | 2-s2.0-17544364554 | - |
dc.type.rims | ART | - |
dc.citation.volume | 46 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 3801 | - |
dc.citation.endingpage | 3808 | - |
dc.citation.publicationname | POLYMER | - |
dc.identifier.doi | 10.1016/j.polymer.2005.02.114 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, TG | - |
dc.contributor.nonIdAuthor | Shin, KC | - |
dc.contributor.nonIdAuthor | Kim, BS | - |
dc.contributor.nonIdAuthor | Kim, JH | - |
dc.contributor.nonIdAuthor | Do Nam, J | - |
dc.contributor.nonIdAuthor | Lee, DS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | macroporous PLGA scaffold | - |
dc.subject.keywordAuthor | thermally induced phase separation (TIPS) | - |
dc.subject.keywordAuthor | liquid-liquid phase separation | - |
dc.subject.keywordPlus | BIODEGRADABLE POLYMER SCAFFOLDS | - |
dc.subject.keywordPlus | CELL TRANSPLANTATION | - |
dc.subject.keywordPlus | POLY(L-LACTIDE) SCAFFOLD | - |
dc.subject.keywordPlus | TERNARY-SYSTEM | - |
dc.subject.keywordPlus | DYNAMICS | - |
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