A facile preparation of highly interconnected macroporous PLGA scaffolds by liquid-liquid phase separation II

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dc.contributor.authorShin, KCko
dc.contributor.authorKim, BSko
dc.contributor.authorKim, JHko
dc.contributor.authorPark, TGko
dc.contributor.authorDo Nam, Jko
dc.contributor.authorLee, DSko
dc.date.accessioned2009-11-10T04:48:57Z-
dc.date.available2009-11-10T04:48:57Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2005-05-
dc.identifier.citationPOLYMER, v.46, no.11, pp.3801 - 3808-
dc.identifier.issn0032-3861-
dc.identifier.urihttp://hdl.handle.net/10203/12337-
dc.description.abstractA regular and well-interconnected macroporous (from 50 to 200 μ m) poly(D,L-lactic acid-co-glycolic acid) (PLGA) scaffold was fabricated by means of the thermally induced phase separation (TIPS) method. Poly(L-lactic acid) (PLLA) was blended with PLGA to increase the viscosity of polymer solution; a block copolymer of poly(ethylene glycol) (PEG) with PLGA was added as a surfactant to decrease the interfacial tension between the polymer-rich and polymer-lean phases. The effect of TIPS parameters including the concentration of diblock copolymer and PLGA/PLLA ratio was also studied. The cloud-point curve shifted to higher temperatures with both increasing the PLLA composition in the PLGA/PLLA blend and the PEG contents in the additives (PEG itself and PEG-PLGA diblocks). This shifting to higher temperature increases the quenching depth during phase separation. Addition of a PEG-PLGA diblock copolymer (0.5 wt% in solution) to the PLGA/PLLA (1/1) blend polymer in a dioxane/water solution stabilized the morphology development during TIPS with respect to interconnection and macropores, and avoided segregation or sedimentation in the late stage. © 2005 Elsevier Ltd. All rights reserved.-
dc.description.sponsorshipthe Korea Research Foundation Grant (KRF-2004-005-D00070).en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherElsevier Sci Ltd-
dc.subjectBIODEGRADABLE POLYMER SCAFFOLDS-
dc.subjectCELL TRANSPLANTATION-
dc.subjectPOLY(L-LACTIDE) SCAFFOLD-
dc.subjectTERNARY-SYSTEM-
dc.subjectDYNAMICS-
dc.titleA facile preparation of highly interconnected macroporous PLGA scaffolds by liquid-liquid phase separation II-
dc.typeArticle-
dc.identifier.wosid000229051200030-
dc.identifier.scopusid2-s2.0-17544364554-
dc.type.rimsART-
dc.citation.volume46-
dc.citation.issue11-
dc.citation.beginningpage3801-
dc.citation.endingpage3808-
dc.citation.publicationnamePOLYMER-
dc.identifier.doi10.1016/j.polymer.2005.02.114-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, TG-
dc.contributor.nonIdAuthorShin, KC-
dc.contributor.nonIdAuthorKim, BS-
dc.contributor.nonIdAuthorKim, JH-
dc.contributor.nonIdAuthorDo Nam, J-
dc.contributor.nonIdAuthorLee, DS-
dc.type.journalArticleArticle-
dc.subject.keywordAuthormacroporous PLGA scaffold-
dc.subject.keywordAuthorthermally induced phase separation (TIPS)-
dc.subject.keywordAuthorliquid-liquid phase separation-
dc.subject.keywordPlusBIODEGRADABLE POLYMER SCAFFOLDS-
dc.subject.keywordPlusCELL TRANSPLANTATION-
dc.subject.keywordPlusPOLY(L-LACTIDE) SCAFFOLD-
dc.subject.keywordPlusTERNARY-SYSTEM-
dc.subject.keywordPlusDYNAMICS-
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