Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres

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dc.contributor.authorChoi, SHko
dc.contributor.authorPark, Tae Gwanko
dc.date.accessioned2009-10-16T06:37:59Z-
dc.date.available2009-10-16T06:37:59Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2000-08-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v.203, no.1-2, pp.193 - 202-
dc.identifier.issn0378-5173-
dc.identifier.urihttp://hdl.handle.net/10203/11839-
dc.description.abstractLeuprolide acetate, an analogue of luteinizing hormone-releasing hormone (LH-RH), was hydrophobically ion paired with a long chain fatty acid, sodium oleate, in an aqueous solution. Solution behaviors of the complex formed between leuprolide and sodium oleate were investigated in terms of aqueous solubility, turbidity, particle size, and zeta potential as a function of molar ratio between the two species. II was found that with increasing the stoichiometric molar amounts of sodium oleate to leuprolide approached up to 2.5-3, the solution became gradually turbid with increasing particle sizes, indicating leuprolide precipitation as a result of hydrophobic ion pairing. On the other hand, beyond that critical molar ratio range, the solution turned into clear with much reduced particle size, indicative of micelle formation. The hydrophobically modified leuprolide-oleate complex was lyophilized and directly encapsulated within biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres via a single oil-in-water (O/W) emulsion method. Microsphere morphology, leuprolide release behavior, and polymer mass erosion profiles were examined in comparison to the PLGA microspheres prepared with free leuprolide. (C) 2000 Elsevier Science B.V. All rights reserved.-
dc.description.sponsorshipresearch fund from Dong Kook Pharmaceutical Co.(Seoul, Korea).en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherELSEVIER SCIENCE BV-
dc.subjectINJECTABLE MICROCAPSULES-
dc.subjectACETATE-
dc.subjectHORMONE-
dc.subjectRATS-
dc.subjectENDOMETRIOSIS-
dc.subjectLEUPRORELIN-
dc.titleHydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres-
dc.typeArticle-
dc.identifier.wosid000089210900015-
dc.type.rimsART-
dc.citation.volume203-
dc.citation.issue1-2-
dc.citation.beginningpage193-
dc.citation.endingpage202-
dc.citation.publicationnameINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.identifier.doi10.1016/S0378-5173(00)00457-9-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorChoi, SH-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorleuprolide acetate-
dc.subject.keywordAuthorPLGA-
dc.subject.keywordAuthormicrospheres-
dc.subject.keywordAuthorhydrophobic ion pairing-
dc.subject.keywordPlusINJECTABLE MICROCAPSULES-
dc.subject.keywordPlusACETATE-
dc.subject.keywordPlusHORMONE-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusENDOMETRIOSIS-
dc.subject.keywordPlusLEUPRORELIN-
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