Temperature Modulated Protein Release from pH and Temperature Sensitive Hydrogels

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A hydrogel which exhibits a volume phase transition in response to pH as well as temperature has been synthesized and utilized as a matrix for the controlled release of insulin. Insulin crystals have been entrapped into the hydrogel matrix during the copolymerization process of N-isopropylacrylamide and the cationic monomer, N,N'-dimethylaminopropylmethacrylamide. The former allows the gel to exhibit a temperature sensitivity, and the latter gives the gel a pH-sensitivity. Insulin release profiles from the gel matrix have been investigated as functions of pH, temperature, and thermal cycling operation. Temperature and thermal cycling operations largely affected the insulin release rate while pH variation did not significantly influence the release profiles. (C) 1999 Elsevier Science Ltd. All rights reserved.
Publisher
Elsevier Sci Ltd
Issue Date
1999
Language
English
Article Type
Article
Keywords

GLUCOSE-OXIDASE; INSULIN; PERMEATION; PH

Citation

BIOMATERIALS, v.20, no.6, pp.517 - 521

ISSN
0142-9612
DOI
10.1016/S0142-9612(98)00197-5
URI
http://hdl.handle.net/10203/11829
Appears in Collection
BS-Journal Papers(저널논문)
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