DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hong Kee | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-10-16 | - |
dc.date.available | 2009-10-16 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.229, no.1-2, pp.107 - 116 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | http://hdl.handle.net/10203/11819 | - |
dc.description.abstract | For the sustained release formulation of recombinant human growth hormone (rhGH), dissociable rhGH aggregates were microencapsulated within poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles. rhGH aggregates were fl-rst produced by adding a small volume of aqueous rhGH solution into a partially water miscible organic solvent phase (ethyl acetate, EtAc) containing PLGA. These rhGH aggregates were then microencapsulated within PLGA polymer phase by extracting EtAc into an aqueous phase pre-saturated with EtAc. Release profiles of rhGH from these microparticles were greatly affected by changing the volume of incubation medium. The released rhGH species consisted of mostly monomeric form having a correct conformation. This study reveals that sustained rhGH release could be achieved by micro encapsulating reversibly dissociable protein aggregates within biodegradable polymers. (C) 2001 Elsevier Science BN. All rights reserved. | - |
dc.description.sponsorship | the Ministry of Health and Welfare, Republic of Korea | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Elsevier Science Bv | - |
dc.subject | AIR-LIQUID INTERFACE | - |
dc.subject | BIODEGRADABLE MICROSPHERES | - |
dc.subject | FORMULATIONS | - |
dc.subject | THERAPEUTICS | - |
dc.title | Microencapsulation of dissociable human growth hormone aggregates within poly(D,L-lactic-co-glycolic acid) microparticles for sustained release | - |
dc.type | Article | - |
dc.identifier.wosid | 000172003100011 | - |
dc.identifier.scopusid | 2-s2.0-0035965502 | - |
dc.type.rims | ART | - |
dc.citation.volume | 229 | - |
dc.citation.issue | 1-2 | - |
dc.citation.beginningpage | 107 | - |
dc.citation.endingpage | 116 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Kim, Hong Kee | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | human growth hormone | - |
dc.subject.keywordAuthor | poly(D,L-lactic-co-glycolic acid) | - |
dc.subject.keywordAuthor | biodegradable polymer | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordPlus | AIR-LIQUID INTERFACE | - |
dc.subject.keywordPlus | BIODEGRADABLE MICROSPHERES | - |
dc.subject.keywordPlus | FORMULATIONS | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
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