DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sakoyama Y. | ko |
dc.contributor.author | Hong K. J. | ko |
dc.contributor.author | Hisajima H. | ko |
dc.contributor.author | Byun, Si Myung | ko |
dc.date.accessioned | 2013-03-14T21:40:44Z | - |
dc.date.available | 2013-03-14T21:40:44Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1987-02 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the USA, pp.1080 - 1084 | - |
dc.identifier.issn | 278424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/113608 | - |
dc.description.abstract | To determine the phylogenetic relationships among hominoids and the dates of their divergence, the complete nucleotide sequences of the constant region of the immunoglobulin epsilon-chain (C epsilon 1) genes from chimpanzee and orangutan have been determined. These sequences were compared with the human epsilon-chain constant-region sequence. A molecular clock (silent molecular clock), measured by the degree of sequence divergence at the synonymous (silent) positions of protein-encoding regions, was introduced for the present study. From the comparison of nucleotide sequences of alpha1-antitrypsin and beta- and delta-globin genes between humans and Old World monkeys, the silent molecular clock was calibrated: the mean evolutionary rate of silent substitution was determined to be 1.56 X 10(-9) substitutions per site per year. Using the silent molecular clock, the mean divergence dates of chimpanzee and orangutan from the human lineage were estimated as 6.4 +/- 2.6 million years and 17.3 +/- 4.5 million years, respectively. It was also shown that the evolutionary rate of primate genes is considerably slower than those of other mammalian genes. | - |
dc.language | English | - |
dc.publisher | PNAS | - |
dc.title | Nucleotide Sequences of Immunoglobulin epsilon Genes of Chimpangee and Orang-Utan: DNA Molecular Clock and Hominoid Evolution | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.beginningpage | 1080 | - |
dc.citation.endingpage | 1084 | - |
dc.citation.publicationname | Proceedings of the National Academy of Sciences of the USA | - |
dc.identifier.conferencecountry | US | - |
dc.contributor.nonIdAuthor | Sakoyama Y. | - |
dc.contributor.nonIdAuthor | Hong K. J. | - |
dc.contributor.nonIdAuthor | Hisajima H. | - |
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