DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, JH | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-09-07T06:03:06Z | - |
dc.date.available | 2009-09-07T06:03:06Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-11 | - |
dc.identifier.citation | BIOCONJUGATE CHEMISTRY, v.12, no.6, pp.917 - 923 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | http://hdl.handle.net/10203/11046 | - |
dc.description.abstract | Biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) was chemically conjugated to oligonucleotide (ODN) to form an amphiphatic structure which is similar to an A-B type block copolymer. A terminal end of PLGA was activated and reacted with primary amine-terminated ODN. The ODN/PLGA conjugates self-assembled in aqueous solution to form a micellar structure by serving PLGA segments as a hydrophobic core and ODN segments as a surrounding hydrophilic corona. Critical micelle concentration was determined by a spectroflurometric method. Atomic force microscopic observation revealed that the micelle size was around 80 nm. These micelles could release ODN in a sustained manner by controlled degradation of hydrophobic PLGA chains. Compared to unconjugated ODN, the ODN/PLGA micelles could be more efficiently transported within cells, presumably by endocytosis. This study proposes a potential delivery method of ODN into cells by forming hybrid ODN/PLGA micelles. | - |
dc.description.sponsorship | the Ministry of Health and Welfare, Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | BLOCK-COPOLYMER MICELLES | - |
dc.subject | MUSCLE CELL-PROLIFERATION | - |
dc.subject | ANTISENSE OLIGODEOXYNUCLEOTIDES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | IN-VITRO | - |
dc.subject | INHIBITION | - |
dc.subject | L-ASPARTATE) | - |
dc.subject | ACCUMULATION | - |
dc.subject | ADRIAMYCIN | - |
dc.title | Novel polymer-DNA hybrid polymeric micelles composed of hydrophobic poly(D,L-lactic-co-glycolic acid) and hydrophilic oligonucleotides | - |
dc.type | Article | - |
dc.identifier.wosid | 000172451200013 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 917 | - |
dc.citation.endingpage | 923 | - |
dc.citation.publicationname | BIOCONJUGATE CHEMISTRY | - |
dc.identifier.doi | 10.1021/bc010052t | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Jeong, JH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | MUSCLE CELL-PROLIFERATION | - |
dc.subject.keywordPlus | ANTISENSE OLIGODEOXYNUCLEOTIDES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | L-ASPARTATE) | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | ADRIAMYCIN | - |
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