DC Field | Value | Language |
---|---|---|
dc.contributor.author | TAE GWAN PARK | ko |
dc.date.accessioned | 2009-09-07T05:30:30Z | - |
dc.date.available | 2009-09-07T05:30:30Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | JOURNAL OF APPLIED POLYMER SCIENCE, v.52, no.12, pp.1797 - 1807 | - |
dc.identifier.issn | 0021-8995 | - |
dc.identifier.uri | http://hdl.handle.net/10203/11041 | - |
dc.description.abstract | Poly (L-lactic acid) -coated polyisobutylcyanoacrylate microcapsules containing protein molecules were prepared by a single-step procedure based on either a double-emulsion-solvent evaporation method or a spray-drying method. First, an aqueous protein solution was emulsified in an organic phase of methylene chloride containing a wall-forming monomer (isobutylcyanoacrylate), various kinds of poly(L-lactic acid), and a surfactant. An immediate polymerization process of isobutylcyanoacrylate takes place at the W/O interface upon contact with hydroxide ion in the aqueous phase, leading to the formation of a polyisobutylcyanoacrylate wall around the aqueous droplets. This W/O emulsion was reemulsified in an aqueous solution to promote the solvent removal and, consequently, the precipitation of poly(L-lactic acid) onto polyisobutylcyanoacrylate microcapsules or was spray-dried to directly deposit the poly (L-lactic acid) on the wall. Three proteins, bovine serum albumin, horseradish peroxidase, and tetanus toxoid, were encapsulated in these poly (L-lactic acid) -coated polyisobutylcyanoacrylate microcapsules, and then their release profiles were examined in vitro as a function of molecular weight of poly(L-lactic acid) and its copolymers with glycolic acid. These formulations exhibited a low ''burst'' effect at initial incubation stages and released the proteins for extended periods of time. Subcutaneous injections of the tetanus toxoid-loaded microparticles into rats showed that the time course of immunization (antibody titer) can be controlled by the type of polymer matrices used. (C) 1994 John Wiley & Sons, Inc. | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | JOHN WILEY & SONS INC | - |
dc.subject | MICROSPHERES | - |
dc.subject | NANOPARTICLES | - |
dc.subject | DEGRADATION | - |
dc.subject | DELIVERY | - |
dc.subject | MATRICES | - |
dc.subject | BLENDS | - |
dc.title | CONTROLLED-RELEASE OF PROTEINS FROM POLY(L-LACTIC ACID) COATED POLYISOBUTYLCYANOACRYLATE MICROCAPSULES | - |
dc.type | Article | - |
dc.identifier.wosid | A1994NM29600014 | - |
dc.identifier.scopusid | 2-s2.0-0028452799 | - |
dc.type.rims | ART | - |
dc.citation.volume | 52 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1797 | - |
dc.citation.endingpage | 1807 | - |
dc.citation.publicationname | JOURNAL OF APPLIED POLYMER SCIENCE | - |
dc.identifier.doi | 10.1002/app.1994.070521214 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | TAE GWAN PARK | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | MATRICES | - |
dc.subject.keywordPlus | BLENDS | - |
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