Thermally induced core-shell type hydrogel beads having interpenetrating polymer network (IPN) structure

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Monodisperse hydrogel beads composed of calcium alginate and crosslinked polyNIPAAm (N-isopropylacrylamide) were synthesized based on a simultaneous interpenetrating network process. With increasing the temperature above the phase transition temperature of polyNIPAAm, a core-shell type of hydrogel beads was developed; polyNIPAAm-enriched core region and Ca-alginate-enriched outer shell layer were observed. The thermally reversible formation of the core-shell double structure in the TPN hydrogel beads was applied for the temperature modulated drug release using indomethacin as a model drug.
Publisher
Wiley-Blackwell
Issue Date
1998-12
Language
English
Article Type
Article
Keywords

RELEASE

Citation

MACROMOLECULAR RAPID COMMUNICATIONS, v.19, no.4, pp.167 - 172

ISSN
1022-1336
URI
http://hdl.handle.net/10203/10502
Appears in Collection
BS-Journal Papers(저널논문)
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