DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ju-Young | ko |
dc.contributor.author | Song, Jee-Yeon | ko |
dc.contributor.author | Kwon, Kyu | ko |
dc.contributor.author | Jang, Su-Mi | ko |
dc.contributor.author | Kim, Cha-Yean | ko |
dc.contributor.author | Baek, Kwang-Hee | ko |
dc.contributor.author | Kim, Jeong-Ho | ko |
dc.contributor.author | Park, Chan-Kyu | ko |
dc.date.accessioned | 2013-03-12T23:50:40Z | - |
dc.date.available | 2013-03-12T23:50:40Z | - |
dc.date.created | 2012-06-21 | - |
dc.date.created | 2012-06-21 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | HUMAN MOLECULAR GENETICS, v.21, no.14, pp.3215 - 3225 | - |
dc.identifier.issn | 0964-6906 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103925 | - |
dc.description.abstract | Human DJ-1 is a genetic cause of early-onset Parkinsons disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting glyoxal or methylglyoxal to glycolic or lactic acid, respectively, in the absence of glutathione. Purified DJ-1 proteins exhibit typical MichaelisMenten kinetics, which were abolished completely in the mutants of essential catalytic residues, consisting of cysteine and glutamic acid. The presence of DJ-1 protected mouse embryonic fibroblast and dopaminergically derived SH-SY5Y cells from treatments of glyoxals. Likewise, C. elegans lacking cDJR-1.1, a DJ-1 homolog expressed primarily in the intestine, protected worms from glyoxal-induced death. Sub-lethal doses of glyoxals caused significant degeneration of the dopaminergic neurons in C. elegans lacking cDJR-1.2, another DJ-1 homolog expressed primarily in the head region, including neurons. Our findings that DJ-1 serves as scavengers for reactive carbonyl species may provide a new insight into the causation of PD. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | PARKINSONS-DISEASE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | CAENORHABDITIS-ELEGANS | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | ALPHA-SYNUCLEIN | - |
dc.subject | PROTEIN DJ-1 | - |
dc.subject | MITOCHONDRIAL LOCALIZATION | - |
dc.subject | DOPAMINERGIC-NEURONS | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | GLYCATION | - |
dc.title | Human DJ-1 and its homologs are novel glyoxalases | - |
dc.type | Article | - |
dc.identifier.wosid | 000305822700010 | - |
dc.identifier.scopusid | 2-s2.0-84864021706 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 14 | - |
dc.citation.beginningpage | 3215 | - |
dc.citation.endingpage | 3225 | - |
dc.citation.publicationname | HUMAN MOLECULAR GENETICS | - |
dc.identifier.doi | 10.1093/hmg/dds155 | - |
dc.contributor.localauthor | Park, Chan-Kyu | - |
dc.contributor.nonIdAuthor | Baek, Kwang-Hee | - |
dc.contributor.nonIdAuthor | Kim, Jeong-Ho | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | PROTEIN DJ-1 | - |
dc.subject.keywordPlus | MITOCHONDRIAL LOCALIZATION | - |
dc.subject.keywordPlus | DOPAMINERGIC-NEURONS | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | GLYCATION | - |
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