DC Field | Value | Language |
---|---|---|
dc.contributor.author | Na, Hee-Kyung | ko |
dc.contributor.author | Kim, Mi-Hee | ko |
dc.contributor.author | Park, Ki-Hyun | ko |
dc.contributor.author | Ryoo, Soo-Ryoon | ko |
dc.contributor.author | Lee, Kyung-Eun | ko |
dc.contributor.author | Jeon, Hye-Sung | ko |
dc.contributor.author | Ryoo, Ryong | ko |
dc.contributor.author | Hyeon, Chang-Bong | ko |
dc.contributor.author | Min, Dal-Hee | ko |
dc.date.accessioned | 2013-03-12T22:01:32Z | - |
dc.date.available | 2013-03-12T22:01:32Z | - |
dc.date.created | 2012-08-07 | - |
dc.date.created | 2012-08-07 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | SMALL, v.8, no.11, pp.1752 - 1761 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103659 | - |
dc.description.abstract | Among various nanoparticles, mesoporous silica nanoparticles (MSNs) have attracted extensive attention for developing efficient drug-delivery systems, mostly due to their high porosity and biocompatibility. However, due to the small pore size, generally below 5 nm in diameter, potential drugs that are loaded into the pore have been limited to small molecules. Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post-transcriptional gene silencing, so-called RNA interference. Highly efficient, sequence-specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | SMALL INTERFERING RNA | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | GENE | - |
dc.subject | CELLS | - |
dc.subject | THERAPEUTICS | - |
dc.subject | CANCER | - |
dc.subject | RESISTANT | - |
dc.subject | PLANTS | - |
dc.title | Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores | - |
dc.type | Article | - |
dc.identifier.wosid | 000304817700016 | - |
dc.identifier.scopusid | 2-s2.0-84861880834 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 1752 | - |
dc.citation.endingpage | 1761 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.201200028 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Ryoo, Ryong | - |
dc.contributor.nonIdAuthor | Kim, Mi-Hee | - |
dc.contributor.nonIdAuthor | Park, Ki-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Kyung-Eun | - |
dc.contributor.nonIdAuthor | Jeon, Hye-Sung | - |
dc.contributor.nonIdAuthor | Hyeon, Chang-Bong | - |
dc.contributor.nonIdAuthor | Min, Dal-Hee | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | mesoporous materials | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | RNA interference | - |
dc.subject.keywordPlus | SMALL INTERFERING RNA | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RESISTANT | - |
dc.subject.keywordPlus | PLANTS | - |
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