DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jihye | ko |
dc.contributor.author | Lammers, Fabienne | ko |
dc.contributor.author | Herr, Winship | ko |
dc.contributor.author | Song, Ji-Joon | ko |
dc.date.accessioned | 2013-03-12T21:41:07Z | - |
dc.date.available | 2013-03-12T21:41:07Z | - |
dc.date.created | 2012-10-26 | - |
dc.date.created | 2012-10-26 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.43, pp.17430 - 17435 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103603 | - |
dc.description.abstract | Host-cell factor 1 (HCF-1) is an unusual transcriptional regulator that undergoes a process of proteolytic maturation to generate N-(HCF-1(N)) and C-(HCF-1(C)) terminal subunits noncovalently associated via self-association sequence elements. Here, we present the crystal structure of the self-association sequence 1 (SAS1) including the adjacent C-terminal HCF-1 nuclear localization signal (NLS). SAS1 elements from each of the HCF-1(N) and HCF-1(C) subunits form an interdigitated fibronectin type 3 (Fn3) tandem repeat structure. We show that the C-terminal NLS recruited by the interdigitated SAS1 structure is required for effective formation of a transcriptional regulatory complex: the herpes simplex virus VP16-induced complex. Thus, HCF-1(N)-HCF-1(C) association via an integrated Fn3 structure permits an NLS to facilitate formation of a transcriptional regulatory complex. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | MSL COMPLEX | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEIN | - |
dc.subject | GROWTH | - |
dc.subject | DOMAIN | - |
dc.subject | VP16 | - |
dc.subject | METHYLTRANSFERASE | - |
dc.subject | SEPARATE | - |
dc.subject | FORMS | - |
dc.title | HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000311147800031 | - |
dc.identifier.scopusid | 2-s2.0-84867905135 | - |
dc.type.rims | ART | - |
dc.citation.volume | 109 | - |
dc.citation.issue | 43 | - |
dc.citation.beginningpage | 17430 | - |
dc.citation.endingpage | 17435 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1208378109 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Song, Ji-Joon | - |
dc.contributor.nonIdAuthor | Lammers, Fabienne | - |
dc.contributor.nonIdAuthor | Herr, Winship | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | crystallography | - |
dc.subject.keywordAuthor | chromatin | - |
dc.subject.keywordAuthor | nuclear localization sequence | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MSL COMPLEX | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | VP16 | - |
dc.subject.keywordPlus | METHYLTRANSFERASE | - |
dc.subject.keywordPlus | SEPARATE | - |
dc.subject.keywordPlus | FORMS | - |
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