DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ae-Ree | ko |
dc.contributor.author | Kim, Hee-Eun | ko |
dc.contributor.author | Lee, Yeon-Mi | ko |
dc.contributor.author | Jeong, Minjee | ko |
dc.contributor.author | Choi, Kwang-Ho | ko |
dc.contributor.author | Park, Jin-Wan | ko |
dc.contributor.author | Choi, Yong-Geun | ko |
dc.contributor.author | Ahn, Hee-Chul | ko |
dc.contributor.author | Choi, Byong-Seok | ko |
dc.contributor.author | Lee, Joon-Hwa | ko |
dc.date.accessioned | 2013-03-12T20:54:26Z | - |
dc.date.available | 2013-03-12T20:54:26Z | - |
dc.date.created | 2012-12-26 | - |
dc.date.created | 2012-12-26 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.428, no.1, pp.137 - 141 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/103486 | - |
dc.description.abstract | The Z-DNA binding domain of human ADAR1 (Z alpha(ADAR1)) preferentially binds Z-DNA rather than B-DNA with high binding affinity. Here, we have carried out chemical shift perturbation and backbone dynamics studies of Z alpha(ADAR1) in the free form and in complex with three DNA duplexes, d(CGCGCG)(2), d(CACGTG)(2), and d(CGTACG)(2). This study reveals that Z alpha(ADAR1) initially binds to d(CGCGCG)(2) through the distinct conformation, especially in the unusually flexible beta 1-loop-alpha 2 region, from the d(CGCGCG)(2)-(Z alpha(ADAR1))(2) complex. This study also suggests that Z alpha(ADAR1) exhibits a distinct conformational change during the B-Z transition of non-CG-repeat DNA duplexes with low binding affinities compared to the CG-repeat DNA duplex. 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | Z-ALPHA DOMAIN | - |
dc.subject | HANDED Z-DNA | - |
dc.subject | HUMAN EDITING ENZYME | - |
dc.subject | B-Z TRANSITION | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | BASE-PAIRS | - |
dc.subject | REVEALS | - |
dc.subject | PROTEINS | - |
dc.subject | COMPLEX | - |
dc.subject | JUNCTION | - |
dc.title | NMR dynamics study of the Z-DNA binding domain of human ADAR1 bound to various DNA duplexes | - |
dc.type | Article | - |
dc.identifier.wosid | 000311523200024 | - |
dc.identifier.scopusid | 2-s2.0-84868370257 | - |
dc.type.rims | ART | - |
dc.citation.volume | 428 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 137 | - |
dc.citation.endingpage | 141 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.10.026 | - |
dc.contributor.localauthor | Choi, Byong-Seok | - |
dc.contributor.nonIdAuthor | Lee, Ae-Ree | - |
dc.contributor.nonIdAuthor | Kim, Hee-Eun | - |
dc.contributor.nonIdAuthor | Lee, Yeon-Mi | - |
dc.contributor.nonIdAuthor | Jeong, Minjee | - |
dc.contributor.nonIdAuthor | Choi, Kwang-Ho | - |
dc.contributor.nonIdAuthor | Park, Jin-Wan | - |
dc.contributor.nonIdAuthor | Choi, Yong-Geun | - |
dc.contributor.nonIdAuthor | Ahn, Hee-Chul | - |
dc.contributor.nonIdAuthor | Lee, Joon-Hwa | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | NMR | - |
dc.subject.keywordAuthor | Z-DNA | - |
dc.subject.keywordAuthor | Backbone dynamics | - |
dc.subject.keywordAuthor | Z-DNA binding protein | - |
dc.subject.keywordAuthor | DNA-protein interaction | - |
dc.subject.keywordPlus | Z-ALPHA DOMAIN | - |
dc.subject.keywordPlus | HANDED Z-DNA | - |
dc.subject.keywordPlus | HUMAN EDITING ENZYME | - |
dc.subject.keywordPlus | B-Z TRANSITION | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | BASE-PAIRS | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | JUNCTION | - |
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