DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chaudhary, Safee Ullah | ko |
dc.contributor.author | Shin, Sung-Young | ko |
dc.contributor.author | Won, Jae-Kyung | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2013-03-12T20:36:34Z | - |
dc.date.available | 2013-03-12T20:36:34Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, v.58, no.10, pp.3028 - 3032 | - |
dc.identifier.issn | 0018-9294 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103449 | - |
dc.description.abstract | There is a renewed interest in tumorigenesis provoked by glycolysis and prosurvival autophagy following the mitochondrial permeability transition during cell death. To investigate such mitochondrial dysfunction, we have developed a multiscale model by integrating the dynamic behaviors of essential oncogenic proteins, cells, and their microenvironment. We found that 1) the concentration of cellular ATP (adenosine triphosphate) available during the autophagy-related processes is a critical factor in determining tumorigenesis; 2) mitochondrial aging rate has a significant influence on this tumorigenic effect, 3) specific hypoxic and oxidative stresses work cooperatively for tumorigenesis during cell death. We conclude that the cellular mitochondrial status is critical in triggering tumorigenesis during the cell death process, particularly under harsh microenvironments. | - |
dc.language | English | - |
dc.publisher | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | - |
dc.subject | SOLID TUMOR | - |
dc.subject | APOPTOSIS | - |
dc.subject | GLUCOSE | - |
dc.subject | GROWTH | - |
dc.subject | ATP | - |
dc.subject | DIE | - |
dc.title | Multiscale Modeling of Tumorigenesis Induced by Mitochondrial Incapacitation in Cell Death | - |
dc.type | Article | - |
dc.identifier.wosid | 000295102600023 | - |
dc.identifier.scopusid | 2-s2.0-80053154261 | - |
dc.type.rims | ART | - |
dc.citation.volume | 58 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 3028 | - |
dc.citation.endingpage | 3032 | - |
dc.citation.publicationname | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Shin, Sung-Young | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | glycolysis | - |
dc.subject.keywordAuthor | mitochondrial apoptosis | - |
dc.subject.keywordAuthor | systems biology | - |
dc.subject.keywordAuthor | tumorigenesis | - |
dc.subject.keywordPlus | SOLID TUMOR | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | ATP | - |
dc.subject.keywordPlus | DIE | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.