Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

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dc.contributor.authorLee, Jeong-Sookko
dc.contributor.authorPark, Ah-Hyungko
dc.contributor.authorLee, Sang-Heeko
dc.contributor.authorLee, Seoung-Hoonko
dc.contributor.authorKim, Jin-Hwanko
dc.contributor.authorYang, Suk-Jinko
dc.contributor.authorYeom, Young-Ilko
dc.contributor.authorKwak, Tae-Hwanko
dc.contributor.authorLee, Dong-Yeopko
dc.contributor.authorLee, Seung Jae Vko
dc.contributor.authorLee, Chul-Hoko
dc.contributor.authorKim, Jin-Manko
dc.contributor.authorKim, Daesooko
dc.date.accessioned2013-03-12T19:09:57Z-
dc.date.available2013-03-12T19:09:57Z-
dc.date.created2012-10-31-
dc.date.created2012-10-31-
dc.date.created2012-10-31-
dc.date.issued2012-10-
dc.identifier.citationPLOS ONE, v.7, no.10-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10203/103233-
dc.description.abstractNADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD(+)/NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the facilitation of NQO1 activity by feeding beta-lapachone (beta L), an exogenous NQO1 co-substrate, prevented age-dependent decline of motor and cognitive function in aged mice. beta L-fed mice did not alter their food-intake or locomotor activity but did increase their energy expenditure as measured by oxygen consumption and heat generation. Mitochondrial structure and numbers were disorganized and decreased in the muscles of control diet group but those defects were less severe in beta L-fed aged mice. Furthermore, for a subset of genes associated with energy metabolism, mice fed the beta L-diet showed similar changes in gene expression to the CR group (fed 70% of the control diet). These results support the potentiation of NQO1 activity by a beta L diet and could be an option for preventing age-related decline of muscle and brain functions.-
dc.languageEnglish-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.titleBeta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice-
dc.typeArticle-
dc.identifier.wosid000309807700055-
dc.identifier.scopusid2-s2.0-84867428923-
dc.type.rimsART-
dc.citation.volume7-
dc.citation.issue10-
dc.citation.publicationnamePLOS ONE-
dc.identifier.doi10.1371/journal.pone.0047122-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Seung Jae V-
dc.contributor.localauthorKim, Daesoo-
dc.contributor.nonIdAuthorLee, Sang-Hee-
dc.contributor.nonIdAuthorLee, Seoung-Hoon-
dc.contributor.nonIdAuthorKim, Jin-Hwan-
dc.contributor.nonIdAuthorYang, Suk-Jin-
dc.contributor.nonIdAuthorYeom, Young-Il-
dc.contributor.nonIdAuthorKwak, Tae-Hwan-
dc.contributor.nonIdAuthorLee, Dong-Yeop-
dc.contributor.nonIdAuthorLee, Chul-Ho-
dc.contributor.nonIdAuthorKim, Jin-Man-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusGENE-EXPRESSION PROFILE-
dc.subject.keywordPlusCALORIE RESTRICTION-
dc.subject.keywordPlusLIFE-SPAN-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusEXTENDS LIFE-
dc.subject.keywordPlusMITOCHONDRIAL-
dc.subject.keywordPlusYEAST-
dc.subject.keywordPlusANTIOXIDANT-
dc.subject.keywordPlusGENE-EXPRESSION PROFILE-
dc.subject.keywordPlusCALORIE RESTRICTION-
dc.subject.keywordPlusLIFE-SPAN-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusEXTENDS LIFE-
dc.subject.keywordPlusMITOCHONDRIAL-
dc.subject.keywordPlusYEAST-
dc.subject.keywordPlusANTIOXIDANT-
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