DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.contributor.author | Quan, Fu-Shi | ko |
dc.contributor.author | Yoo, Dae-Goon | ko |
dc.contributor.author | Compans, Richard W. | ko |
dc.contributor.author | Kang, Sang-Moo | ko |
dc.contributor.author | Prausnitz, Mark R. | ko |
dc.date.accessioned | 2013-03-12T15:50:00Z | - |
dc.date.available | 2013-03-12T15:50:00Z | - |
dc.date.created | 2012-07-02 | - |
dc.date.created | 2012-07-02 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | JOURNAL OF INFECTIOUS DISEASES, v.201, no.2, pp.190 - 198 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/10203/102778 | - |
dc.description.abstract | Background. Morbidity and mortality due to influenza could be reduced by improved vaccination. Methods. To develop a novel skin delivery method that is simple and allows for easy self-administration, we prepared microneedle patches with stabilized influenza vaccine and investigated their protective immune responses. Results. Mice vaccinated with a single microneedle dose of trehalose-stabilized influenza vaccine developed strong antibody responses that were long-lived. Compared with traditional intramuscular vaccination, stabilized microneedle vaccination was superior in inducing protective immunity, as was evidenced by efficient clearance of virus from the lung and enhanced humoral and antibody-secreting cell immune responses after 100% survival from lethal challenge. Vaccine stabilization was found to be important, because mice vaccinated with an unstabilized microneedle vaccine elicited a weaker immunoglobulin G 2a antibody response, compared with the stabilized microneedle vaccine, and were only partially protected against viral challenge. Improved trafficking of dendritic cells to regional lymph nodes as a result of microneedle delivery to the skin might play a role in contributing to improved protective immunity. Conclusions. These findings suggest that vaccination of the skin using a microneedle patch can improve protective efficacy and induce long-term sustained immunogenicity and may also provide a simple method of administration to improve influenza vaccination coverage. | - |
dc.language | English | - |
dc.publisher | UNIV CHICAGO PRESS | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | IN-VIVO | - |
dc.subject | IMMUNIZATION | - |
dc.subject | VIRUS | - |
dc.subject | DELIVERY | - |
dc.subject | ANTIBODY | - |
dc.subject | ARRAYS | - |
dc.subject | SAFETY | - |
dc.subject | PATCH | - |
dc.title | Enhanced Memory Responses to Seasonal H1N1 Influenza Vaccination of the Skin with the Use of Vaccine-Coated Microneedles | - |
dc.type | Article | - |
dc.identifier.wosid | 000273051200005 | - |
dc.identifier.scopusid | 2-s2.0-75649140606 | - |
dc.type.rims | ART | - |
dc.citation.volume | 201 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 190 | - |
dc.citation.endingpage | 198 | - |
dc.citation.publicationname | JOURNAL OF INFECTIOUS DISEASES | - |
dc.identifier.doi | 10.1086/649228 | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Quan, Fu-Shi | - |
dc.contributor.nonIdAuthor | Yoo, Dae-Goon | - |
dc.contributor.nonIdAuthor | Compans, Richard W. | - |
dc.contributor.nonIdAuthor | Kang, Sang-Moo | - |
dc.contributor.nonIdAuthor | Prausnitz, Mark R. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | IMMUNIZATION | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | ARRAYS | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | PATCH | - |
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