DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, Hye-Young | ko |
dc.contributor.author | Kim, Ji-Hoon | ko |
dc.contributor.author | Woo, Jae-Sung | ko |
dc.contributor.author | Ku, Bonsu | ko |
dc.contributor.author | Shin, Eun Ju | ko |
dc.contributor.author | Yun, Yungdae | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.date.accessioned | 2013-03-12T14:06:00Z | - |
dc.date.available | 2013-03-12T14:06:00Z | - |
dc.date.created | 2012-08-23 | - |
dc.date.created | 2012-08-23 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v.80, no.8, pp.2099 - 2104 | - |
dc.identifier.issn | 0887-3585 | - |
dc.identifier.uri | http://hdl.handle.net/10203/102539 | - |
dc.description.abstract | Post-translational modification by small ubiquitin-like modifier (SUMO) can be reversed by sentrin/SUMO-specific proteases (SENPs), the first known class of deSUMOylase. Recently, we identified a new deSUMOylating enzyme DeSI-1, which is distinct from SENPs and belongs to the putative deubiquitinating isopeptidase PPPDE superfamily. Herein, we report the crystal structure of DeSI-1, revealing that this enzyme forms a homodimer and that the groove between the two subunits is the active site harboring two absolutely conserved cysteine and histidine residues that form a catalytic dyad. We also show that DeSI-1 exhibits an extremely low endopeptidase activity toward precursor forms of SUMO-1 and SUMO-2, unlike SENPs. Proteins 2012. (c) 2012 Wiley Periodicals, Inc. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | UBIQUITIN | - |
dc.subject | PROTEASE | - |
dc.subject | PAPAIN | - |
dc.title | Crystal structure of DeSI-1, a novel deSUMOylase belonging to a putative isopeptidase superfamily | - |
dc.type | Article | - |
dc.identifier.wosid | 000306132400017 | - |
dc.identifier.scopusid | 2-s2.0-84863775612 | - |
dc.type.rims | ART | - |
dc.citation.volume | 80 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 2099 | - |
dc.citation.endingpage | 2104 | - |
dc.citation.publicationname | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | - |
dc.identifier.doi | 10.1002/prot.24093 | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Suh, Hye-Young | - |
dc.contributor.nonIdAuthor | Kim, Ji-Hoon | - |
dc.contributor.nonIdAuthor | Woo, Jae-Sung | - |
dc.contributor.nonIdAuthor | Ku, Bonsu | - |
dc.contributor.nonIdAuthor | Shin, Eun Ju | - |
dc.contributor.nonIdAuthor | Yun, Yungdae | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | ubiquitin-like protein | - |
dc.subject.keywordAuthor | SUMO | - |
dc.subject.keywordAuthor | deSUMOylase | - |
dc.subject.keywordAuthor | DeSI-1 | - |
dc.subject.keywordAuthor | PPPDE | - |
dc.subject.keywordAuthor | structure | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | PROTEASE | - |
dc.subject.keywordPlus | PAPAIN | - |
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