DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bang, So-Young | ko |
dc.contributor.author | Han, Tae-Un | ko |
dc.contributor.author | Choi, Chan-Bum | ko |
dc.contributor.author | Sung, Yoon-Kyoung | ko |
dc.contributor.author | Bae, Sang-Cheol | ko |
dc.contributor.author | KANG, Changwon | ko |
dc.date.accessioned | 2013-03-12T06:16:41Z | - |
dc.date.available | 2013-03-12T06:16:41Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | ARTHRITIS RESEARCH & THERAPY, v.12, no.3 | - |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101503 | - |
dc.description.abstract | Introduction: Anti-cyclic citrullinated peptide autoantibodies (anti-CCP) are the most specific serologic marker for rheumatoid arthritis (RA). Genetic polymorphisms in a citrullinating (or deiminating) enzyme, peptidyl arginine deiminase type IV (PADI4) have been reproducibly associated with RA susceptibility in several populations. We investigated whether PADI4 polymorphisms contribute to anti-CCP-negative as well as -positive RA, whether they influence disease severity (erosive joint status), and whether they interact with two major risk factors for RA, Human Leukocyte Antigen-DRB1 (HLA-DRB1) shared epitope (SE) alleles and smoking, depending on anti-CCP and erosive joint status. Methods: All 2,317 unrelated Korean subjects including 1,313 patients with RA and 1,004 unaffected controls were genotyped for three nonsynonymous (padi4_89, padi4_90, and padi4_92) and one synonymous (padi4_104) single-nucleotide polymorphisms (SNPs) in PADI4 and for HLA-DRB1 by direct DNA sequence analysis. Odds ratios (OR) were calculated by multivariate logistic regression. Interaction was evaluated by attributable proportions (AP), with 95% confidence intervals (CI). Results: A functional haplotype of the three fully correlated nonsynonymous SNPs in PADI4 was significantly associated with susceptibility to not only anti-CCP-positive (adjusted OR 1.73, 95% CI 1.34 to 2.23) but also -negative RA (adjusted OR 1.75, 95% CI 1.15 to 2.68). A strong association with both non-erosive (adjusted OR 1.62, 95% CI 1.29 to 2.05) and erosive RA (adjusted OR 1.62, 95% CI 1.14 to 2.31) was observed for PADI4 haplotype. Gene-gene interactions between the homozygous RA-risk PADI4 haplotype and SE alleles were significant in both anti-CCP-positive (AP 0.45, 95% CI 0.20 to 0.71) and -negative RA (AP 0.61, 95% CI 0.29 to 0.92). Theses interactions were also observed for both non-erosive (AP 0.48, 95% CI 0.25 to 0.72) and erosive RA (AP 0.46, 95% CI 0.14 to 0.78). In contrast, no interaction was observed between smoking and PADI4 polymorphisms. Conclusions: A haplotype of nonsynonymous SNPs in PADI4 contributes to development of RA regardless of anti-CCP or erosive joint status. The homozygous PADI4 haplotype contribution is affected by gene-gene interactions with HLA-DRB1 SE alleles. | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.title | Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study | - |
dc.type | Article | - |
dc.identifier.wosid | 000280227900060 | - |
dc.identifier.scopusid | 2-s2.0-77953271204 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 3 | - |
dc.citation.publicationname | ARTHRITIS RESEARCH & THERAPY | - |
dc.identifier.doi | 10.1186/ar3051 | - |
dc.contributor.localauthor | KANG, Changwon | - |
dc.contributor.nonIdAuthor | Bang, So-Young | - |
dc.contributor.nonIdAuthor | Choi, Chan-Bum | - |
dc.contributor.nonIdAuthor | Sung, Yoon-Kyoung | - |
dc.contributor.nonIdAuthor | Bae, Sang-Cheol | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | FUNCTIONAL HAPLOTYPE | - |
dc.subject.keywordPlus | HLA-DRB1 ALLELES | - |
dc.subject.keywordPlus | JAPANESE POPULATION | - |
dc.subject.keywordPlus | CIGARETTE-SMOKING | - |
dc.subject.keywordPlus | FRENCH POPULATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
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