DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, Young-Jun | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Park, Ji-Hyun | ko |
dc.contributor.author | Han, Jin-Ah | ko |
dc.contributor.author | Lee, In-Kyu | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.contributor.author | Koh, Gou-Young | ko |
dc.date.accessioned | 2013-03-12T04:08:42Z | - |
dc.date.available | 2013-03-12T04:08:42Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.41, no.12, pp.880 - 895 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101286 | - |
dc.description.abstract | We sought to determine the effects of activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on multilocularization of adipocytes in adult white adipose tissue (WAT). Male C57BL/6 normal, db/db, and ob/ob mice were treated with agonists of PPAR-gamma, PPAR-alpha, or beta(3)-adrenoceptor for 3 weeks. To distinguish multilocular adipocytes from unilocular adipocytes, whole-mounted adipose tissues were co-immunostained for perilipin and collagen IV. PPAR-gamma activation with rosiglitazone or pioglitazone induced a profound change of unilocular adipocytes into smaller, multilocular adipocytes in adult WAT in a time-dependent, dose-dependent, and reversible manner. PPAR-a activation with fenofibrate did not affect the number of locules or remodeling. db/db and ob/ob obese mice exhibited less multilocularization in response to PPAR-gamma activation compared to normal mice. Nevertheless, all adipocytes activated by PPAR-gamma contained a single nucleus regardless of locule number. Multilocular adipocytes induced by PPAR-gamma activation contained substantially increased mitochondrial content and enhanced expression of uncoupling protein-1, PPAR-gamma co-activator-1-alpha, and perilipin. Taken together, PPAR-gamma activation induces profound multilocularization and enhanced mitochondrial biogenesis in the adipocytes of adult WAT. These changes may affect the overall function of WAT. | - |
dc.language | English | - |
dc.publisher | Korean Soc Med Biochemistry Molecular Biology | - |
dc.title | Activation of PPAR gamma induces profound multilocularization of adipocytes in adult mouse white adipose tissues | - |
dc.type | Article | - |
dc.identifier.wosid | 000273334600005 | - |
dc.identifier.scopusid | 2-s2.0-75149127688 | - |
dc.type.rims | ART | - |
dc.citation.volume | 41 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 880 | - |
dc.citation.endingpage | 895 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.3858/emm.2009.41.12.094 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.localauthor | Koh, Gou-Young | - |
dc.contributor.nonIdAuthor | Park, Ji-Hyun | - |
dc.contributor.nonIdAuthor | Lee, In-Kyu | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | mitochondrial uncoupling protein | - |
dc.subject.keywordAuthor | pioglitazone | - |
dc.subject.keywordAuthor | receptors, adrenergic, beta-3 | - |
dc.subject.keywordAuthor | rosiglitazone | - |
dc.subject.keywordPlus | INSULIN SENSITIZER ROSIGLITAZONE | - |
dc.subject.keywordPlus | MITOCHONDRIAL BIOGENESIS | - |
dc.subject.keywordPlus | RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | BROWN | - |
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