DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyung-Eun | ko |
dc.contributor.author | Koh, Young-Jun | ko |
dc.contributor.author | Jeon, Bong-Hyun | ko |
dc.contributor.author | Jang, Chol-Soon | ko |
dc.contributor.author | Han, Jin-Ah | ko |
dc.contributor.author | Kataru, Raghu Prasad | ko |
dc.contributor.author | Schwendener, Reto A. | ko |
dc.contributor.author | Kim, Jin-Man | ko |
dc.contributor.author | Koh, Gou-Young | ko |
dc.date.accessioned | 2013-03-12T03:20:09Z | - |
dc.date.available | 2013-03-12T03:20:09Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | AMERICAN JOURNAL OF PATHOLOGY, v.175, no.4, pp.1733 - 1745 | - |
dc.identifier.issn | 0002-9440 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101190 | - |
dc.description.abstract | Lymphatic vessels in the diaphragm are essential for draining peritoneal fluid, but little is known about their pathological changes during inflammation. Here we characterized diaphragmatic lymphatic vessels in a peritonitis model generated by daily i.p. administration of lipopolysaccharide (LPS) in mice. Intraperitoneal LPS increased lymphatic density, branching, sprouts, connections, and network formation in the diaphragm in time- and dose-dependent manners. These changes were reversible on discontinuation of LPS administration. The LPS-induced lymphatic density and remodeling occur mainly through proliferation of lymphatic endothelial cells. CD11b(+) macrophages were massively accumulated and closely associated with the lymphatic vessels changed by i.p. LPS. Both RT-PCR assays and experiments with vascular endothelial growth factor-C/D blockade and macrophage-depletion indicated that the CD11b(+) macrophage-derived lymphangiogenic factors vascular endothelial growth factor-C/D could he major mediators of LPS-induced lymphangiogenesis and lymphatic remodeling through paracrine activity. Functional assays with India Ink and fluorescein isothiocyanate-microspheres indicated that impaired peritoneal fluid drainage in diaphragm of LPS-induced peritonitis mice was due to inflammatory fibrosis and massive attachment of CD11b(+) macrophages on the peritoneal side of the diaphragmatic lymphatic vessels.. These findings reveal that CD11b(+) macrophages play an important role in i.p. LPS-induced aberrant lymphangiogenesis and lymphatic dysfunction in the diaphragm. (Am J Pathol 2009, 175:1733-1733; DOI: 10.2353/ajpath.2009.090133) | - |
dc.language | English | - |
dc.publisher | AMER SOC INVESTIGATIVE PATHOLOGY, INC | - |
dc.subject | PERITONEAL-CAVITY | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | CRUCIAL ROLE | - |
dc.subject | INFLAMMATION | - |
dc.subject | ABSORPTION | - |
dc.subject | SYSTEM | - |
dc.subject | VEGF | - |
dc.subject | MICE | - |
dc.subject | RECRUITMENT | - |
dc.subject | CLEARANCE | - |
dc.title | Role of CD11b(+) Macrophages in Intraperitoneal Lipopolysaccharide-Induced Aberrant Lymphangiogenesis and Lymphatic Function in the Diaphragm | - |
dc.type | Article | - |
dc.identifier.wosid | 000270503100038 | - |
dc.identifier.scopusid | 2-s2.0-73549105244 | - |
dc.type.rims | ART | - |
dc.citation.volume | 175 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 1733 | - |
dc.citation.endingpage | 1745 | - |
dc.citation.publicationname | AMERICAN JOURNAL OF PATHOLOGY | - |
dc.identifier.doi | 10.2353/ajpath.2009.090133 | - |
dc.contributor.localauthor | Koh, Gou-Young | - |
dc.contributor.nonIdAuthor | Jang, Chol-Soon | - |
dc.contributor.nonIdAuthor | Schwendener, Reto A. | - |
dc.contributor.nonIdAuthor | Kim, Jin-Man | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PERITONEAL-CAVITY | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | CRUCIAL ROLE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | CLEARANCE | - |
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