DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Su Jung | ko |
dc.contributor.author | Song, Min Sup | ko |
dc.contributor.author | Kim, Soon Jung | ko |
dc.contributor.author | Kim, So Yeon | ko |
dc.contributor.author | Kwon, Seung Hae | ko |
dc.contributor.author | Kim, Jhin Gook | ko |
dc.contributor.author | Calvisi, Diego F. | ko |
dc.contributor.author | Kang, Dongmin | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.date.accessioned | 2013-03-09T20:37:25Z | - |
dc.date.available | 2013-03-09T20:37:25Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | CANCER RESEARCH, v.69, no.6, pp.2314 - 2323 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97419 | - |
dc.description.abstract | The Aurora (Ip1) kinase family plays important roles in the regulation of mitosis and tumorigenesis. The tumor suppressor RASSF1A controls mitotic progression by regulating anaphase-promoting complex (APC)-Cdc20 activity and microtubule stability, but the mechanism by which this action is regulated has not been previously established. Here, we show that Aurora A and B associate with and phosphorylate RASSF1A on serine 203 in vivo at different times and in different subcellular compartments during mitosis. Notably, both depletion of Aurora A by RNA interference and expression of a nonphosphorylatable RASSF1A (S203A) mutant gene led to a marked delay in prometaphase progression. This is likely because of the failure of RASSF1A to dissociate from Cdc20, constitutive inhibition of APC-Cdc20, and accumulation of mitotic cyclins. In contrast, the delay in prometaphase progression caused by Aurora A depletion was largely normalized by phosphomimetic RASSF1A (S203D). Finally, RASSF1A phosphorylation on serine 203 was upregulated in Aurora A-overexpressing human tumors. These findings indicate that Aurora A plays a critical role in RASSF1A-APC-Cdc20 regulatory mechanisms that control normal prometaphase progression and that are involved in tumorigenesis. [Cancer Res 2009;69(6):2314-23] | - |
dc.language | English | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.subject | ANAPHASE-PROMOTING COMPLEX | - |
dc.subject | SPINDLE ASSEMBLY CHECKPOINT | - |
dc.subject | SMALL-MOLECULE INHIBITOR | - |
dc.subject | TUMOR-SUPPRESSOR | - |
dc.subject | A KINASE | - |
dc.subject | MICROTUBULE STABILITY | - |
dc.subject | MITOTIC ENTRY | - |
dc.subject | MITOSIS | - |
dc.subject | PROTEIN | - |
dc.subject | DEGRADATION | - |
dc.title | Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity | - |
dc.type | Article | - |
dc.identifier.wosid | 000264541300023 | - |
dc.identifier.scopusid | 2-s2.0-65549154498 | - |
dc.type.rims | ART | - |
dc.citation.volume | 69 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 2314 | - |
dc.citation.endingpage | 2323 | - |
dc.citation.publicationname | CANCER RESEARCH | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-08-3984 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Song, Min Sup | - |
dc.contributor.nonIdAuthor | Kwon, Seung Hae | - |
dc.contributor.nonIdAuthor | Kim, Jhin Gook | - |
dc.contributor.nonIdAuthor | Calvisi, Diego F. | - |
dc.contributor.nonIdAuthor | Kang, Dongmin | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANAPHASE-PROMOTING COMPLEX | - |
dc.subject.keywordPlus | SPINDLE ASSEMBLY CHECKPOINT | - |
dc.subject.keywordPlus | SMALL-MOLECULE INHIBITOR | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | A KINASE | - |
dc.subject.keywordPlus | MICROTUBULE STABILITY | - |
dc.subject.keywordPlus | MITOTIC ENTRY | - |
dc.subject.keywordPlus | MITOSIS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DEGRADATION | - |
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