DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chae, Su-Young | ko |
dc.contributor.author | Kim, Hyun-June | ko |
dc.contributor.author | Lee, Min-Sang | ko |
dc.contributor.author | Jang, Yeon-Lim | ko |
dc.contributor.author | Lee, Yu-Han | ko |
dc.contributor.author | Lee, Soo-Hyeon | ko |
dc.contributor.author | Lee, Kyu-Ri | ko |
dc.contributor.author | Kim, Sun-Hwa | ko |
dc.contributor.author | Kim, Hong-Tae | ko |
dc.contributor.author | Chi, Sang-Cheol | ko |
dc.contributor.author | Park, Tae-Gwan | ko |
dc.contributor.author | Jeong, Ji-Hoon | ko |
dc.date.accessioned | 2013-03-09T08:13:22Z | - |
dc.date.available | 2013-03-09T08:13:22Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-09 | - |
dc.identifier.citation | MACROMOLECULAR BIOSCIENCE, v.11, no.9, pp.1169 - 1174 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | http://hdl.handle.net/10203/95826 | - |
dc.description.abstract | Efficient gene transfer into mammalian cells mediated by small molecular amphiphile-polymer conjugates, bile acid-polyethylenimine (BA-PEI), is demonstrated, opening an efficient transport route for genetic materials across the cell membrane. This process occurs without the aid of endocytosis or other energy-consuming processes, thus mimicking macromolecular transduction by cell-penetrating peptides. The exposure of a hydrophilic face of the amphiphilic BA moiety on the surface of BA-PEI/DNA complex that mediates direct contact of the BA molecules to the cell surface seems to play an important role in the endocytosis- and energy-independent internalization process. The new modality of the polymeric biomimetics can be applied to enhanced delivery of macromolecular therapeutics. | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.subject | FACIAL AMPHIPHILES | - |
dc.subject | LOW-TEMPERATURE | - |
dc.subject | DNA COMPLEXES | - |
dc.subject | POLYETHYLENIMINE | - |
dc.subject | TRANSFECTION | - |
dc.subject | MECHANISMS | - |
dc.subject | SYSTEMS | - |
dc.title | Energy-Independent Intracellular Gene Delivery Mediated by Polymeric Biomimetics of Cell-Penetrating Peptides | - |
dc.type | Article | - |
dc.identifier.wosid | 000294985200003 | - |
dc.identifier.scopusid | 2-s2.0-80052447684 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 1169 | - |
dc.citation.endingpage | 1174 | - |
dc.citation.publicationname | MACROMOLECULAR BIOSCIENCE | - |
dc.contributor.localauthor | Park, Tae-Gwan | - |
dc.contributor.nonIdAuthor | Chae, Su-Young | - |
dc.contributor.nonIdAuthor | Kim, Hyun-June | - |
dc.contributor.nonIdAuthor | Lee, Min-Sang | - |
dc.contributor.nonIdAuthor | Jang, Yeon-Lim | - |
dc.contributor.nonIdAuthor | Lee, Yu-Han | - |
dc.contributor.nonIdAuthor | Kim, Sun-Hwa | - |
dc.contributor.nonIdAuthor | Kim, Hong-Tae | - |
dc.contributor.nonIdAuthor | Chi, Sang-Cheol | - |
dc.contributor.nonIdAuthor | Jeong, Ji-Hoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | amphiphiles | - |
dc.subject.keywordAuthor | biomimetics | - |
dc.subject.keywordAuthor | gene delivery | - |
dc.subject.keywordAuthor | micelles | - |
dc.subject.keywordAuthor | polymers | - |
dc.subject.keywordPlus | FACIAL AMPHIPHILES | - |
dc.subject.keywordPlus | LOW-TEMPERATURE | - |
dc.subject.keywordPlus | DNA COMPLEXES | - |
dc.subject.keywordPlus | POLYETHYLENIMINE | - |
dc.subject.keywordPlus | TRANSFECTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SYSTEMS | - |
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