CRY1 inhibits COP1-mediated degradation of BIT1, a MYB transcription factor, to activate blue light-dependent gene expression in Arabidopsis

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Cryptochromes (CRY) are one of the two major classes of photoreceptors that perceive light stimuli in the UV-A to blue light region and they are involved in multiple aspects of plant growth and development. However, knowledge regarding their signaling transduction components and mechanisms remains limited. Here, we report that a MYB transcription factor Blue Insensitive Trait 1 (BIT1), plays an important role in controlling blue light responses. Hypocotyl growth responses indicate that BIT1 functions as a positive element in blue light signaling, since BIT1 antisense and knock-out lines show a reduced light response in blue light. BIT1 controls blue light-dependent expression of various genes such as PsbS, a member of the light-harvesting complex gene family. A transactivation assay showed that BIT1 regulates promoter activity of PsbS in a blue light-dependent manner and that it requires CRY1 for activation of the PsbS promoter. BIT1 undergoes degradation in darkness and CRY1 functions to stabilize BIT1 in a blue light-dependent manner. In contrast, COP1 binds to BIT1 and mediates its degradation. We propose that the PsbS promoter is activated in blue light via the blue light-dependent stabilization of BIT1 by CRY1, while in darkness BIT1 is degraded by COP1-mediated proteolysis.
Publisher
BLACKWELL PUBLISHING
Issue Date
2008-08
Language
English
Article Type
Article
Keywords

MEDIATED PHOTOMORPHOGENIC GROWTH; SIGNAL-TRANSDUCTION; HIGHER-PLANTS; PHYTOCHROME; COP1; CRYPTOCHROME; PROTEIN; THALIANA; HYPOCOTYL; PATHWAYS

Citation

PLANT JOURNAL, v.55, no.3, pp.361 - 371

ISSN
0960-7412
DOI
10.1111/j.1365-313X.2008.03508.x
URI
http://hdl.handle.net/10203/90433
Appears in Collection
BS-Journal Papers(저널논문)
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