Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye

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Two types of basic helix-loop-helix (bHLH) family transcription factor have functions in neurogenesis. Class II bHLH proteins are expressed in tissue-specific patterns, whereas class I proteins are broadly expressed as general cofactors for class II proteins. Here, we show that the Drosophila class I factor Daughterless (Da) is upregulated by Hedgehog (Hh) and Decapentaplegic (Dpp) signalling during retinal neurogenesis. Our data suggest that Da is accumulated in the cells surrounding the neuronal precursor cells to repress the proneural gene atonal (ato), thereby generating a single R8 neuron from each proneural cluster. Upregulation of Da depends on Notch signalling, and, in turn, induces the expression of the Enhancer-of-split proteins for the repression of ato. We propose that the dual functions of Da-as a proneural and as an anti-proneural factor-are crucial for initial neural patterning in the eye.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2008-11
Language
English
Article Type
Article
Keywords

ACHAETE-SCUTE COMPLEX; MORPHOGENETIC FURROW; NEURAL DEVELOPMENT; SEX DETERMINATION; HEDGEHOG; PROGRESSION; ROLES; DIFFERENTIATION; INITIATION; RETINA

Citation

EMBO REPORTS, v.9, no.11, pp.1128 - 1133

ISSN
1469-221X
DOI
10.1038/embor.2008.166
URI
http://hdl.handle.net/10203/90313
Appears in Collection
BS-Journal Papers(저널논문)
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