Requirement of caspases and p38 MAPK for TRAIL-mediated ICAM-1 expression by human astroglial cells

Cited 5 time in webofscience Cited 0 time in scopus
  • Hit : 155
  • Download : 0
Among tumor necrosis factor (TNF) superfamily, TNF-related apoptosis inducing ligand (TRAIL) along with TNF-alpha and FasL is known as death ligand due to its selective cytotoxicity against transformed tumor cells. TRAIL can also induce alternative angiogenic and/or proinflammatory signals other than apoptosis, however, the molecular mechanisms responsible for the alternative signals have not been detailed yet. Intercellular adhesion molecule-1 (ICAM-1) is thought to be involved in the processes of metastasis and angiogenesis in various tumors. We investigated the molecular mechanisms responsible for ICAM-1 expression by death ligands in human astroglial cells to delineate the alternative signals of these ligands. Here, we demonstrate that (1) death ligands induced expression of ICAM-I at the mRNA and protein levels in human astroglial cells; (2) pre-treatment of z-VAD-fmk and/or SB202190 suppressed death ligand-induced ICAM-I expression and subsequent adhesion of activated monocytic cells; and (3) inhibition of caspase suppressed death ligand-induced phosphorylation of p38 MAPK and IKK. These findings suggest biological function of death receptors other than apoptosis in human astroglial cells, and the involvement of caspase and/or p38 MAPK in alternative signaling through death receptors. (c) 2008 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2008-05
Language
English
Article Type
Article
Keywords

INTERCELLULAR-ADHESION MOLECULE-1; ACTIVATED PROTEIN-KINASE; HUMAN GLIOMA-CELLS; NF-KAPPA-B; PROINFLAMMATORY CYTOKINES; FAS LIGATION; APOPTOSIS; INDUCTION; PATHWAYS; INVOLVEMENT

Citation

IMMUNOLOGY LETTERS, v.117, no.2, pp.168 - 173

ISSN
0165-2478
DOI
10.1016/j.imlet.2008.01.010
URI
http://hdl.handle.net/10203/90283
Appears in Collection
BiS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 5 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0