DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Kyungsun | ko |
dc.contributor.author | Song, Seungjeong | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.date.accessioned | 2013-03-07T13:27:24Z | - |
dc.date.available | 2013-03-07T13:27:24Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.citation | IMMUNOLOGY LETTERS, v.117, no.2, pp.168 - 173 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90283 | - |
dc.description.abstract | Among tumor necrosis factor (TNF) superfamily, TNF-related apoptosis inducing ligand (TRAIL) along with TNF-alpha and FasL is known as death ligand due to its selective cytotoxicity against transformed tumor cells. TRAIL can also induce alternative angiogenic and/or proinflammatory signals other than apoptosis, however, the molecular mechanisms responsible for the alternative signals have not been detailed yet. Intercellular adhesion molecule-1 (ICAM-1) is thought to be involved in the processes of metastasis and angiogenesis in various tumors. We investigated the molecular mechanisms responsible for ICAM-1 expression by death ligands in human astroglial cells to delineate the alternative signals of these ligands. Here, we demonstrate that (1) death ligands induced expression of ICAM-I at the mRNA and protein levels in human astroglial cells; (2) pre-treatment of z-VAD-fmk and/or SB202190 suppressed death ligand-induced ICAM-I expression and subsequent adhesion of activated monocytic cells; and (3) inhibition of caspase suppressed death ligand-induced phosphorylation of p38 MAPK and IKK. These findings suggest biological function of death receptors other than apoptosis in human astroglial cells, and the involvement of caspase and/or p38 MAPK in alternative signaling through death receptors. (c) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | INTERCELLULAR-ADHESION MOLECULE-1 | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | HUMAN GLIOMA-CELLS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | PROINFLAMMATORY CYTOKINES | - |
dc.subject | FAS LIGATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | INDUCTION | - |
dc.subject | PATHWAYS | - |
dc.subject | INVOLVEMENT | - |
dc.title | Requirement of caspases and p38 MAPK for TRAIL-mediated ICAM-1 expression by human astroglial cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000255578500007 | - |
dc.identifier.scopusid | 2-s2.0-41449095631 | - |
dc.type.rims | ART | - |
dc.citation.volume | 117 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 168 | - |
dc.citation.endingpage | 173 | - |
dc.citation.publicationname | IMMUNOLOGY LETTERS | - |
dc.identifier.doi | 10.1016/j.imlet.2008.01.010 | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Choi, Kyungsun | - |
dc.contributor.nonIdAuthor | Song, Seungjeong | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | TRAIL | - |
dc.subject.keywordAuthor | ICAM-1 | - |
dc.subject.keywordAuthor | p38 | - |
dc.subject.keywordAuthor | caspase | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordPlus | INTERCELLULAR-ADHESION MOLECULE-1 | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | HUMAN GLIOMA-CELLS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PROINFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | FAS LIGATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
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