Allele-specific deposition of macroH2A1 in imprinting control regions

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In the current study, we analyzed the deposition patterns of macroH2A1 at a number of different genomic loci located in X chromosome and autosomes. MacroH2A1 is preferentially deposited at methylated CpG-rich regions located close to promoters. The macroH2A1 deposition patterns at the methylated CpG islands of several imprinted domains, including the imprinting control regions (ICRs) of Xist, Peg3, H19/Igf2, Gtl2/Dlk1 and Gnas domains, show consistent allele-specificity towards inactive, methylated alleles. The macroH2A1 deposition levels at the ICRs and other differentially methylated regions of these domains are also either higher or comparable to those observed at the inactive X chromosome of female mammals. Overall, our results indicate that besides DNA methylation macroH2A1 is another epigenetic component in the chromatin of ICRs displaying differential association with two parental alleles.
Publisher
OXFORD UNIV PRESS
Issue Date
2006-03
Language
English
Article Type
Article
Keywords

INACTIVE X-CHROMOSOME; HISTONE VARIANT MACROH2A; CALORIE RESTRICTION; BARR BODY; METHYLATION; BINDING; DOMAIN; GENE; IGF2; H19

Citation

HUMAN MOLECULAR GENETICS, v.15, no.5, pp.717 - 724

ISSN
0964-6906
DOI
10.1093/hmg/ddi485
URI
http://hdl.handle.net/10203/88488
Appears in Collection
BS-Journal Papers(저널논문)
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