DC Field | Value | Language |
---|---|---|
dc.contributor.author | Inhee, MJ | ko |
dc.contributor.author | Shin, JE | ko |
dc.contributor.author | Yun, SH | ko |
dc.contributor.author | Huh, K | ko |
dc.contributor.author | Koh, JY | ko |
dc.contributor.author | Park, HK | ko |
dc.contributor.author | Jew, SS | ko |
dc.contributor.author | Jung, MW | ko |
dc.date.accessioned | 2013-03-03T09:15:22Z | - |
dc.date.available | 2013-03-03T09:15:22Z | - |
dc.date.created | 2013-02-20 | - |
dc.date.created | 2013-02-20 | - |
dc.date.issued | 1999-11 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE RESEARCH, v.58, no.3, pp.417 - 425 | - |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | http://hdl.handle.net/10203/78154 | - |
dc.description.abstract | Asiaticoside (AS) derivatives were tested for potential protective effects against A beta-induced cell death. Of the 28 AS derivatives tested, asiatic acid (AA), asiaticoside 6 (AS6), and SM2 showed strong inhibition of A beta-induced death of B103 cells at 1 mu M, The three AS derivatives were further tested for their effects on free radical injury and apoptosis, All three AS derivatives reduced H2O2-induced cell death and lowered intracellular free radical concentration, but AA showed the strongest protection. In contrast, SM2 was the most effective blocker of staurosporine-induced apoptosis, These results suggest that the three AS derivatives block A beta toxicity by acting through different cellular mechanisms. When applied to hippocampal slices, AA, SM2, and AS6 did not alter n-methyl-D-aspartic acid (NMDA) or non-NMDA receptor-mediated synaptic transmission, paired-pulse facilitation or induction of long-term potentiation in the field CA1. These results indicate that the three AS derivatives do not alter physiological properties of the hippocampus at the concentration that blocks A beta-induced cell death, Therefore AS6, AA, and SM2 can be regarded as reasonable candidates for a therapeutic Alzheimer's disease drug that protects neurons from A beta toxicity. J, Neurosci, Res. 58:417-425, 1999, (C) 1999 Wiley-Liss, Inc. | - |
dc.language | English | - |
dc.publisher | WILEY-LISS | - |
dc.subject | FAMILIAL ALZHEIMERS-DISEASE | - |
dc.subject | PRECURSOR PROTEIN | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | A-BETA | - |
dc.subject | PEPTIDE | - |
dc.subject | PRESENILIN-1 | - |
dc.subject | HIPPOCAMPAL | - |
dc.subject | APOPTOSIS | - |
dc.subject | PLAQUES | - |
dc.subject | NEURONS | - |
dc.title | Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity | - |
dc.type | Article | - |
dc.identifier.wosid | 000083308700007 | - |
dc.identifier.scopusid | 2-s2.0-0033231331 | - |
dc.type.rims | ART | - |
dc.citation.volume | 58 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 417 | - |
dc.citation.endingpage | 425 | - |
dc.citation.publicationname | JOURNAL OF NEUROSCIENCE RESEARCH | - |
dc.contributor.localauthor | Jung, MW | - |
dc.contributor.nonIdAuthor | Inhee, MJ | - |
dc.contributor.nonIdAuthor | Shin, JE | - |
dc.contributor.nonIdAuthor | Yun, SH | - |
dc.contributor.nonIdAuthor | Huh, K | - |
dc.contributor.nonIdAuthor | Koh, JY | - |
dc.contributor.nonIdAuthor | Park, HK | - |
dc.contributor.nonIdAuthor | Jew, SS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | asiaticoside | - |
dc.subject.keywordAuthor | LTP | - |
dc.subject.keywordAuthor | free radical | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordPlus | FAMILIAL ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | PRESENILIN-1 | - |
dc.subject.keywordPlus | HIPPOCAMPAL | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | NEURONS | - |
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