The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila

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A small number of major regulatory (selector) genes have been identified in animals that control the development of particular organs or complex structures. In Drosophila, the vestigial gene is required for wing formation and is able to induce wing-like outgrowths on other structures. However, the molecular function of the nuclear Vestigial protein, which bears no informative similarities to other proteins, was unknown. Here, we show that Vestigial requires the function of the Scalloped protein, a member of the TEA family of transcriptional regulators, to directly activate the expression of genes involved in wing morphogenesis. Genetic and molecular analyses reveal that Vestigial regulates wing identity by forming a complex with the Scalloped protein that binds sequence specifically to essential sites in wing-specific enhancers. These enhancers also require the direct inputs of signaling pathways, and the response of an enhancer can be switched to another pathway through changes in signal-transducer binding sites. Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis.
Publisher
COLD SPRING HARBOR LAB PRESS
Issue Date
1998-12
Language
English
Article Type
Article
Keywords

LONG-RANGE ACTION; DNA-BINDING DOMAIN; ENHANCER FACTOR-I; TRANSCRIPTION FACTORS; COMPARTMENT BOUNDARY; MORPHOGEN GRADIENT; NOTCH; ACTIVATION; TEF-1; ORGANIZES

Citation

GENES DEVELOPMENT, v.12, no.24, pp.3900 - 3909

ISSN
0890-9369
DOI
10.1101/gad.12.24.3900
URI
http://hdl.handle.net/10203/69479
Appears in Collection
BS-Journal Papers(저널논문)
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