DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, I | ko |
dc.contributor.author | Yoon, YS | ko |
dc.contributor.author | Kang, KW | ko |
dc.contributor.author | Park, SD | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.date.accessioned | 2013-02-24T14:28:17Z | - |
dc.date.available | 2013-02-24T14:28:17Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1993-10 | - |
dc.identifier.citation | PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.58, no.4, pp.536 - 540 | - |
dc.identifier.issn | 0031-8655 | - |
dc.identifier.uri | http://hdl.handle.net/10203/57858 | - |
dc.description.abstract | The exposure of NIH 3T3 fibroblast cells to 254 nm UV radiation resulted in a temporary depression of DNA synthesis and inhibition of 80 kDa protein phosphorylation. This inhibition of protein phosphorylation was correlated with decreased protein kinase C activity in the membrane fractions of UV-damaged cells. The inositol triphosphate contents measured, by the competitive binding assay using bovine adrenal binding protein, showed 80% reduction in the fibroblasts treated with 15 J/m2 of UV light. The intracellular diacylglycerol concentration was also markedly reduced in UV-damaged cells. The results suggest that UV light causes acute reductions of inositol triphosphate and diacylglycerol contents in cells along with decreases in membrane protein kinase C activity, which leads to the inhibition of phosphorylation of an acidic protein of 80 kDa. | - |
dc.language | English | - |
dc.publisher | AMER SOC PHOTOBIOLOGY | - |
dc.subject | KINASE-C | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | ULTRAVIOLET-LIGHT | - |
dc.subject | PHORBOL ESTERS | - |
dc.subject | SIGNAL TRANSDUCTION | - |
dc.subject | SWISS 3T3-CELLS | - |
dc.subject | DNA-REPLICATION | - |
dc.subject | ACTIVATION | - |
dc.subject | TRANSFORMATION | - |
dc.subject | TRANSLOCATION | - |
dc.title | Inhibition of 80 kDa protein phosphorylation by short-wavelength UV light in NIH 3T3 cells | - |
dc.type | Article | - |
dc.identifier.wosid | A1993MC10700012 | - |
dc.identifier.scopusid | 2-s2.0-0027674624 | - |
dc.type.rims | ART | - |
dc.citation.volume | 58 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 536 | - |
dc.citation.endingpage | 540 | - |
dc.citation.publicationname | PHOTOCHEMISTRY AND PHOTOBIOLOGY | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Shin, I | - |
dc.contributor.nonIdAuthor | Yoon, YS | - |
dc.contributor.nonIdAuthor | Kang, KW | - |
dc.contributor.nonIdAuthor | Park, SD | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | KINASE-C | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | ULTRAVIOLET-LIGHT | - |
dc.subject.keywordPlus | PHORBOL ESTERS | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCTION | - |
dc.subject.keywordPlus | SWISS 3T3-CELLS | - |
dc.subject.keywordPlus | DNA-REPLICATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
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